Peptide hormone precursor processing: getting sorted?

Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent...

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Published in:Molecular and cellular endocrinology Vol. 156; no. 1; pp. 1 - 6
Main Authors: Canaff, Lucie, Bennett, Hugh P.J, Hendy, Geoffrey N
Format: Journal Article
Language:English
Published: Ireland Elsevier Ireland Ltd 25-10-1999
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Abstract Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans.
AbstractList Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans.
Author Bennett, Hugh P.J
Canaff, Lucie
Hendy, Geoffrey N
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Snippet Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated...
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SubjectTerms 7B2
Animals
Carboxypeptidase
Carboxypeptidase H
Carboxypeptidases - metabolism
Endopeptidases - metabolism
Granin
Hormones - genetics
Hormones - metabolism
Humans
Mice
Mice, Knockout
Molecular Chaperones - metabolism
Mutation
Nerve Tissue Proteins - metabolism
Neuroendocrine Secretory Protein 7B2
Peptides - genetics
Peptides - metabolism
Pituitary Hormones - metabolism
Proprotein convertase
Protein Precursors - metabolism
Protein Processing, Post-Translational
Title Peptide hormone precursor processing: getting sorted?
URI https://dx.doi.org/10.1016/S0303-7207(99)00129-X
https://www.ncbi.nlm.nih.gov/pubmed/10612417
https://search.proquest.com/docview/69380068
Volume 156
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