Peptide hormone precursor processing: getting sorted?
Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent...
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Published in: | Molecular and cellular endocrinology Vol. 156; no. 1; pp. 1 - 6 |
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25-10-1999
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Abstract | Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans. |
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AbstractList | Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans. |
Author | Bennett, Hugh P.J Canaff, Lucie Hendy, Geoffrey N |
Author_xml | – sequence: 1 givenname: Lucie surname: Canaff fullname: Canaff, Lucie – sequence: 2 givenname: Hugh P.J surname: Bennett fullname: Bennett, Hugh P.J – sequence: 3 givenname: Geoffrey N surname: Hendy fullname: Hendy, Geoffrey N email: gnhendy@med.mcgill.ca |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10612417$$D View this record in MEDLINE/PubMed |
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SubjectTerms | 7B2 Animals Carboxypeptidase Carboxypeptidase H Carboxypeptidases - metabolism Endopeptidases - metabolism Granin Hormones - genetics Hormones - metabolism Humans Mice Mice, Knockout Molecular Chaperones - metabolism Mutation Nerve Tissue Proteins - metabolism Neuroendocrine Secretory Protein 7B2 Peptides - genetics Peptides - metabolism Pituitary Hormones - metabolism Proprotein convertase Protein Precursors - metabolism Protein Processing, Post-Translational |
Title | Peptide hormone precursor processing: getting sorted? |
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