Peptide hormone precursor processing: getting sorted?

• Published in: Molecular and cellular endocrinology Vol. 156; no. 1; pp. 1 - 6
• Main Authors: Canaff, Lucie, Bennett, Hugh P.J, Hendy, Geoffrey N
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 25-10-1999
• Subjects: 7B2; Animals; Carboxypeptidase; Carboxypeptidase H; Carboxypeptidases - metabolism; Endopeptidases - metabolism; Granin; Hormones - genetics; Hormones - metabolism; Humans; Mice; Mice, Knockout; Molecular Chaperones - metabolism; Mutation; Nerve Tissue Proteins - metabolism; Neuroendocrine Secretory Protein 7B2; Peptides - genetics; Peptides - metabolism; Pituitary Hormones - metabolism; Proprotein convertase; Protein Precursors - metabolism; Protein Processing, Post-Translational; Granin; Carboxypeptidase; Proprotein convertase; 7B2
• ISSN: 0303-7207; 1872-8057
• DOI: 10.1016/S0303-7207(99)00129-X

Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans.