Insulin-like growth factor-1 stimulates vascular smooth muscle cell proliferation in rat aorta in vivo
IGF-I is a mitogen for vascular smooth muscle cells (SMC) in vitro and enhances SMC proliferation in vivo in diabetic rats. In this study, we examined the effect of IGF-I on SMC proliferation in vivo in normal rats. Recombinant human IGF-I (0.87 and 3.1 mg/kg/day), was infused via osmotic minipumps...
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| Published in: | Growth hormone & IGF research Vol. 8; no. 4; pp. 299 - 303 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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01-08-1998
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| Abstract | IGF-I is a mitogen for vascular smooth muscle cells (SMC)
in vitro and enhances SMC proliferation
in vivo in diabetic rats. In this study, we examined the effect of IGF-I on SMC proliferation
in vivo in normal rats. Recombinant human IGF-I (0.87 and 3.1 mg/kg/day), was infused via osmotic minipumps in normal rats starting 3 days before they were subjected to arotic injury with a balloon catheter. IGF-I at an infusion rate of 3.1 mg/kg/day caused a significant increase in
3H-thymidine incorporation into DNA (+53%,
P<0.01) in the rat aortic intima-media 2 days after injury and DNA content (+13%,
P<0.05) after 11 days. The elastin and collagen contents were not changed by IGF-I infusion after 11 days. Body weight increased slightly while blood glucose was not affected. At an infusion rate of 0.87 mg/kg/day, IGF-I had no significant effects. These results suggest that circulating levels of IGF-I can stimulate SMC proliferation
in vivo in normal rats but only at high concentrations. |
|---|---|
| AbstractList | IGF-I is a mitogen for vascular smooth muscle cells (SMC) in vitro and enhances SMC proliferation in vivo in diabetic rats. In this study, we examined the effect of IGF-I on SMC proliferation in vivo in normal rats. Recombinant human IGF-I (0.87 and 3.1 mg/kg/day), was infused via osmotic minipumps in normal rats starting 3 days before they were subjected to aortic injury with a balloon catheter. IGF-I at an infusion rate of 3.1 mg/kg/day caused a significant increase in 3H-thymidine incorporation into DNA (+53%, P < 0.01) in the rat aortic intima-media 2 days after injury and DNA content (+13%, P < 0.05) after 11 days. The elastin and collagen contents were not changed by IGF-I infusion after 11 days. Body weight increased slightly while blood glucose was not affected. At an infusion rate of 0.87 mg/kg/day, IGF-I had no significant effects. These results suggest that circulating levels of IGF-I can stimulate SMC proliferation in vivo in normal rats but only at high concentrations. IGF-I is a mitogen for vascular smooth muscle cells (SMC) in vitro and enhances SMC proliferation in vivo in diabetic rats. In this study, we examined the effect of IGF-I on SMC proliferation in vivo in normal rats. Recombinant human IGF-I (0.87 and 3.1 mg/kg/day), was infused via osmotic minipumps in normal rats starting 3 days before they were subjected to arotic injury with a balloon catheter. IGF-I at an infusion rate of 3.1 mg/kg/day caused a significant increase in 3H-thymidine incorporation into DNA (+53%, P<0.01) in the rat aortic intima-media 2 days after injury and DNA content (+13%, P<0.05) after 11 days. The elastin and collagen contents were not changed by IGF-I infusion after 11 days. Body weight increased slightly while blood glucose was not affected. At an infusion rate of 0.87 mg/kg/day, IGF-I had no significant effects. These results suggest that circulating levels of IGF-I can stimulate SMC proliferation in vivo in normal rats but only at high concentrations. |
| Author | Magnusson, J.O. Capron, L. Chen, Y. Wallby, L.A. Arnqvist, H.J. |
| Author_xml | – sequence: 1 givenname: Y. surname: Chen fullname: Chen, Y. organization: Center de Recherches sur les Maladies Vasculaires Peripheriques, Association Claude Bernard, Hôpital Broussais, Paris, France – sequence: 2 givenname: L. surname: Capron fullname: Capron, L. organization: Department of Internal Medicine, Faculty of Health Sciences, University of Linköping, Linköping, Sweden – sequence: 3 givenname: J.O. surname: Magnusson fullname: Magnusson, J.O. organization: Department of Cell Biology, Faculty of Health Sciences, University of Linköping, Linköping, Sweden – sequence: 4 givenname: L.A. surname: Wallby fullname: Wallby, L.A. organization: Department of Cell Biology, Faculty of Health Sciences, University of Linköping, Linköping, Sweden – sequence: 5 givenname: H.J. surname: Arnqvist fullname: Arnqvist, H.J. organization: Department of Cell Biology, Faculty of Health Sciences, University of Linköping, Linköping, Sweden |
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| Cites_doi | 10.1161/01.RES.72.6.1285 10.2337/diabetes.35.9.973 10.1161/01.RES.66.6.1755 10.1093/geronj/45.4.B113 10.1016/S0046-8177(87)80006-0 10.1172/JCI119663 10.1677/joe.0.1250381 10.1097/00000441-199402000-00001 10.1172/JCI111764 10.1210/endo-120-6-2251 10.1172/JCI117081 10.1172/JCI117070 10.1172/JCI115613 10.1161/01.RES.68.1.106 10.1677/joe.0.1350203 10.1161/01.RES.42.5.644 10.1073/pnas.86.10.3813 10.1161/01.CIR.79.6.1374 10.2337/diabetes.41.12.1511 10.1161/01.RES.71.3.646 10.1007/BF00402540 10.1039/an9618600768 10.1097/00005344-199406000-00019 10.1172/JCI116070 |
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| Snippet | IGF-I is a mitogen for vascular smooth muscle cells (SMC)
in vitro and enhances SMC proliferation
in vivo in diabetic rats. In this study, we examined the... IGF-I is a mitogen for vascular smooth muscle cells (SMC) in vitro and enhances SMC proliferation in vivo in diabetic rats. In this study, we examined the... |
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| SubjectTerms | Animals Body Weight - drug effects Cell Division - drug effects DNA - drug effects DNA - metabolism Dose-Response Relationship, Drug Humans Infusion Pumps Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - injuries Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology |
| Title | Insulin-like growth factor-1 stimulates vascular smooth muscle cell proliferation in rat aorta in vivo |
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