Synthesis and calcium channel antagonist activities of 3-nitrooxyalkyl, 5-alkyl 1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-2-imidazolyl)-3,5-pyridinedicarboxylates

A group of racemic 3-[(2-nitrooxyethyl), (3-nitrooxypropyl), (4-nitrooxybutyl) or (1,3-dinitrooxy-2-propyl)], 5-methyl (ethyl or propyl) 1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-2-imidazolyl)-3,5-pyridinedicarboxylates ( 18– 29) were synthesized using modified Hantzsch reaction that involved the...

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Bibliographic Details
Published in:	Farmaco (Società chimica italiana : 1989) Vol. 57; no. 2; pp. 123 - 128
Main Authors:	Miri, Ramin, Niknahad, H, Vesal, Gh, Shafiee, A
Format:	Journal Article
Language:	English
Published:	France Elsevier SAS 01-02-2002
Subjects:	Animals Calcium Channel Blockers - chemical synthesis Calcium Channel Blockers - pharmacology Calcium channels Calcium Channels - metabolism Dihydropyridine Guinea Pigs Ileum - drug effects Inhibitory Concentration 50 Male Molecular Structure Muscle Contraction - drug effects Muscle, Smooth - drug effects Nitroimidazole Nitrooxyalkyl Organ Culture Techniques Organic nitrate Pyridines - chemical synthesis Pyridines - pharmacology Structure-Activity Relationship Calcium channels Dihydropyridine Nitrooxyalkyl Nitroimidazole Organic nitrate
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