Structure of magnetically guided nanocarriers of the photodithazine sensitizer from small-angle neutron scattering data

Nanosized complexes of ferromagnetic particles with a photodithazine sensitizer (used in photo-dynamic therapy in oncology) have been synthesized and investigated using small-angle neutron scattering for the first time. The structure of the complexes has been determined, and the influence of the bio...

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Bibliographic Details
Published in:	Physics of the solid state Vol. 52; no. 5; pp. 1040 - 1044
Main Authors:	Kulvelis, Yu. V., Trounov, V. A., Lebedev, V. T., Orlova, D. N., Török, Gy, Gelfond, M. L.
Format:	Journal Article
Language:	English
Published:	Dordrecht SP MAIK Nauka/Interperiodica 01-05-2010 Springer
Subjects:	Biology Chemistry and Physics of Polymers and Fullerenes Ferroalloys Ferromagnetism Iron compounds Pharmacology Physics Physics and Astronomy Solid State Physics Scatter Cross Section Small Angle Neutron Scattering Pluronic Magnetic Fluid Magnetite Particle
Online Access:	Get full text
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Summary:	Nanosized complexes of ferromagnetic particles with a photodithazine sensitizer (used in photo-dynamic therapy in oncology) have been synthesized and investigated using small-angle neutron scattering for the first time. The structure of the complexes has been determined, and the influence of the biocompatible polymer Pluronic on their structure has been analyzed. The possibilities of using the complexes for magnetically guided delivery of the photosensitizer to cells and tissues in the treatment of oncological diseases by photodynamic therapy have been discussed.
ISSN:	1063-7834 1090-6460
DOI:	10.1134/S1063783410050331