Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system
High dose corticosteroid (CS) administration is a common mode of therapy in treatment of acute relapses in multiple sclerosis (MS) but the effects of CS on remyelination and the cellular mechanisms mediating this repair process are controversial. We have examined CS effects on repair of toxin‐induce...
Saved in:
| Published in: | Journal of neuroscience research Vol. 83; no. 4; pp. 594 - 605 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01-03-2006
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | High dose corticosteroid (CS) administration is a common mode of therapy in treatment of acute relapses in multiple sclerosis (MS) but the effects of CS on remyelination and the cellular mechanisms mediating this repair process are controversial. We have examined CS effects on repair of toxin‐induced demyelinating lesions in the adult rat spinal cord. Corticosteroids reduced the extent of oligodendrocyte remyelination at 1 month post lesion (whereas Schwann‐cell mediated repair was unaffected). However, CS did not cause permanent impairment of remyelination as lesions were fully remyelinated at 2 months after cessation of treatment. The delay in oligodendrocyte mediated repair could be attributed to inhibition of differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes, with no effect of CS treatment observed on OPC colonisation of the lesions. No differences were observed in animals treated with methylprednisolone succinate alone or with a subsequent prednisone taper indicating that CS effects occur at an early stage of repair. The potential consequences of delayed remyelination in inflammatory lesions are discussed. © 2006 Wiley‐Liss, Inc. |
|---|---|
| AbstractList | High dose corticosteroid (CS) administration is a common mode of therapy in treatment of acute relapses in multiple sclerosis (MS) but the effects of CS on remyelination and the cellular mechanisms mediating this repair process are controversial. We have examined CS effects on repair of toxin‐induced demyelinating lesions in the adult rat spinal cord. Corticosteroids reduced the extent of oligodendrocyte remyelination at 1 month post lesion (whereas Schwann‐cell mediated repair was unaffected). However, CS did not cause permanent impairment of remyelination as lesions were fully remyelinated at 2 months after cessation of treatment. The delay in oligodendrocyte mediated repair could be attributed to inhibition of differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes, with no effect of CS treatment observed on OPC colonisation of the lesions. No differences were observed in animals treated with methylprednisolone succinate alone or with a subsequent prednisone taper indicating that CS effects occur at an early stage of repair. The potential consequences of delayed remyelination in inflammatory lesions are discussed. © 2006 Wiley‐Liss, Inc. High dose corticosteroid (CS) administration is a common mode of therapy in treatment of acute relapses in multiple sclerosis (MS) but the effects of CS on remyelination and the cellular mechanisms mediating this repair process are controversial. We have examined CS effects on repair of toxin-induced demyelinating lesions in the adult rat spinal cord. Corticosteroids reduced the extent of oligodendrocyte remyelination at 1 month post lesion (whereas Schwann-cell mediated repair was unaffected). However, CS did not cause permanent impairment of remyelination as lesions were fully remyelinated at 2 months after cessation of treatment. The delay in oligodendrocyte mediated repair could be attributed to inhibition of differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes, with no effect of CS treatment observed on OPC colonisation of the lesions. No differences were observed in animals treated with methylprednisolone succinate alone or with a subsequent prednisone taper indicating that CS effects occur at an early stage of repair. The potential consequences of delayed remyelination in inflammatory lesions are discussed. |
| Author | Franklin, Robin J.M. Chari, Divya M. Blakemore, William F. Zhao, Chao Kotter, Mark R. |
| Author_xml | – sequence: 1 givenname: Divya M. surname: Chari fullname: Chari, Divya M. email: dmc35@hermes.cam.ac.uk organization: Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom – sequence: 2 givenname: Chao surname: Zhao fullname: Zhao, Chao organization: Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom – sequence: 3 givenname: Mark R. surname: Kotter fullname: Kotter, Mark R. organization: Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom – sequence: 4 givenname: William F. surname: Blakemore fullname: Blakemore, William F. organization: Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom – sequence: 5 givenname: Robin J.M. surname: Franklin fullname: Franklin, Robin J.M. organization: Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16429447$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kMtOwzAQRS1UREthwQ-gbFmk9TOJl6iCAiqFIhDsLDeeiJQ0ruwAzd9jaHls2MxodM9czdx91KltDQgdETwgGNPhonYDitOE7aAewTKNueBpB_UwS3DMMaFdtO_9AmMspWB7qEsSTiXnaQ8VI-uaMre-AWdL4yMDlW4jB8sWqrLWTWnryBYRrFfgyiXUja4C81ct66h5hshZE9QoD8UFpgb3Zl995NtgvTxAu4WuPBxuex89nJ_djy7iyc34cnQ6iXOWEBYbmsuCGGBJKo3OsExEQYXISCEoF3lmKEjDpJxjjsPINcUaJMkyxowUFFgfnWx8c2e9d1CoVbhau1YRrD6zUiEr9ZVVYI837Op1vgTzS27DCcBwA7yXFbT_O6mr6d23ZbzZKMPT658N7V5UkrJUqMfpWF3PxjMi5JO6ZR83oYZl |
| CitedBy_id | crossref_primary_10_1016_j_neuroscience_2009_04_016 crossref_primary_10_1016_j_neulet_2010_07_060 crossref_primary_10_1093_brain_awn096 crossref_primary_10_1212_01_CON_0000293640_98116_18 crossref_primary_10_1016_j_jneuroim_2007_09_016 crossref_primary_10_1016_j_bbadis_2010_09_010 crossref_primary_10_1111_j_1365_2826_2011_02140_x crossref_primary_10_1002_glia_24165 crossref_primary_10_3389_fnins_2021_604103 crossref_primary_10_1159_000537794 crossref_primary_10_1038_s41598_018_35734_4 crossref_primary_10_1016_j_bbi_2007_03_010 crossref_primary_10_1038_nn_3263 crossref_primary_10_1007_s00415_007_1009_6 crossref_primary_10_3389_fphar_2022_934971 crossref_primary_10_1016_j_expneurol_2016_05_001 crossref_primary_10_1210_en_2005_1625 crossref_primary_10_1093_brain_awr014 crossref_primary_10_1111_neup_12926 crossref_primary_10_1093_brain_aws313 crossref_primary_10_1111_j_1750_3639_2007_00065_x crossref_primary_10_1002_glia_20371 crossref_primary_10_1016_j_neuroscience_2019_05_050 crossref_primary_10_1093_jnen_nly081 crossref_primary_10_1210_en_2011_1219 crossref_primary_10_1021_cn400167n crossref_primary_10_1016_j_clineuro_2013_12_021 crossref_primary_10_1212_WNL_0b013e3181a8260a crossref_primary_10_1523_JNEUROSCI_0103_17_2017 crossref_primary_10_3390_cells12111515 crossref_primary_10_1016_j_mcn_2017_11_006 crossref_primary_10_1523_ENEURO_0203_18_2018 crossref_primary_10_1016_j_neuron_2014_06_007 crossref_primary_10_1007_s12017_010_8112_z crossref_primary_10_1038_nrn2480 crossref_primary_10_1016_j_neuropharm_2015_09_016 crossref_primary_10_1016_j_neuroscience_2014_03_063 crossref_primary_10_1002_glia_22748 crossref_primary_10_1111_bpa_12454 crossref_primary_10_1002_jmri_27286 crossref_primary_10_1097_IJG_0b013e3180391a18 crossref_primary_10_14336_AD_2024_0216 crossref_primary_10_1016_j_steroids_2015_08_013 crossref_primary_10_1097_WCO_0b013e32813aee7f crossref_primary_10_1093_brain_awt024 crossref_primary_10_3389_fncel_2020_00284 |
| Cites_doi | 10.1073/pnas.91.19.8812 10.1093/brain/123.2.308 10.1136/jnnp.55.6.450 10.1006/mcne.2002.1145 10.1006/exnr.1999.7224 10.1001/archneur.1986.00520020015008 10.1177/107385849900500315 10.1016/0736-5748(94)90084-1 10.1002/glia.1085 10.1016/S0002-9440(10)64030-8 10.1001/archneur.58.1.91 10.1056/NEJM199801293380502 10.1016/S0736-5748(01)00026-0 10.1038/nrn917 10.1002/ana.410050105 10.1002/neu.10158 10.1212/WNL.42.2.348 10.1212/WNL.57.7.1239 10.1523/JNEUROSCI.21-18-07046.2001 10.1146/annurev.med.53.082901.103909 10.1074/jbc.272.34.21654 10.1016/S0896-6273(00)80359-1 10.1242/dev.120.5.1097 10.1016/j.jneuroim.2004.08.011 10.1007/BF00869001 10.1002/jnr.490380308 10.1016/S0002-9440(10)64537-3 10.1038/280395a0 10.1126/science.3975627 10.1001/archopht.1992.01080180129040 10.1016/S0165-5728(03)00125-5 10.1523/JNEUROSCI.02-09-01292.1982 10.1002/jnr.10338 10.1016/0304-3940(90)90499-Y 10.1016/j.neuint.2003.08.018 10.1007/BF01355538 10.1002/glia.10148 10.1002/(SICI)1097-4695(19981115)37:3<413::AID-NEU7>3.0.CO;2-8 10.1177/1073858404263494 10.1016/0165-5728(92)90144-A 10.1083/jcb.200312012 10.1111/j.1365-2990.2005.00637.x 10.1006/mcne.2000.0897 10.1126/science.280.5369.1610 10.1016/S0165-5728(01)00396-4 10.1038/nn738 10.1002/glia.10067 10.1016/S0014-4886(03)00347-9 10.1055/s-2004-822759 10.1002/ana.410330203 10.1523/JNEUROSCI.23-12-04967.2003 10.1523/JNEUROSCI.23-30-09824.2003 10.1073/pnas.95.18.10459 10.1093/brain/120.3.393 10.1097/00005072-199305000-00003 10.1097/00001756-200012180-00013 10.1523/JNEUROSCI.18-07-02498.1998 10.1093/brain/awf043 10.1002/1098-1136(200009)31:3<219::AID-GLIA30>3.0.CO;2-R 10.1038/nrn784 10.1002/ana.10578 10.1016/j.nbd.2004.09.019 10.1093/brain/120.1.27 10.1016/0165-3806(87)90197-0 10.1111/j.1365-2990.1986.tb00162.x 10.1177/135245859700300213 10.1006/mcne.1999.0771 |
| ContentType | Journal Article |
| Copyright | copyright © 2006 Wiley‐Liss, Inc. Copyright 2006 Wiley-Liss, Inc. |
| Copyright_xml | – notice: copyright © 2006 Wiley‐Liss, Inc. – notice: Copyright 2006 Wiley-Liss, Inc. |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION |
| DOI | 10.1002/jnr.20763 |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1097-4547 |
| EndPage | 605 |
| ExternalDocumentID | 10_1002_jnr_20763 16429447 JNR20763 ark_67375_WNG_MQGQ159X_P |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Junior Research Fellowship, Multiple Sclerosis Society of UK and Northern Ireland – fundername: Multiple Sclerosis Society grantid: 689 – fundername: Multiple Sclerosis Society grantid: 725 |
| GroupedDBID | --- -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABIVO ABJNI ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACIWK ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BSCLL BY8 C45 CS3 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE G-S G.N GAKWD GNP GODZA H.T H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6M MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RWD RWI RX1 RYL SAMSI SUPJJ SV3 TEORI UB1 V2E W8V W99 WBKPD WIB WIH WIK WJL WNSPC WOHZO WQJ WRC WUP WXSBR WYISQ X7M XG1 XV2 YYP ZGI ZXP ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM AAYXX CITATION |
| ID | FETCH-LOGICAL-c3613-d2c9f1de3679da80965f25581f5245c8d2e9d399b0405c84a20ae918833d952e3 |
| IEDL.DBID | 33P |
| ISSN | 0360-4012 |
| IngestDate | Fri Aug 23 01:47:16 EDT 2024 Sat Sep 28 08:22:33 EDT 2024 Sat Aug 24 00:51:26 EDT 2024 Wed Oct 30 09:54:04 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Copyright 2006 Wiley-Liss, Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3613-d2c9f1de3679da80965f25581f5245c8d2e9d399b0405c84a20ae918833d952e3 |
| Notes | istex:4830B37925B42A9B63D706110F4AF56A35D3773E Junior Research Fellowship, Multiple Sclerosis Society of UK and Northern Ireland ark:/67375/WNG-MQGQ159X-P ArticleID:JNR20763 |
| PMID | 16429447 |
| PageCount | 12 |
| ParticipantIDs | crossref_primary_10_1002_jnr_20763 pubmed_primary_16429447 wiley_primary_10_1002_jnr_20763_JNR20763 istex_primary_ark_67375_WNG_MQGQ159X_P |
| PublicationCentury | 2000 |
| PublicationDate | 2006-03 March 2006 2006-Mar 2006-03-00 |
| PublicationDateYYYYMMDD | 2006-03-01 |
| PublicationDate_xml | – month: 03 year: 2006 text: 2006-03 |
| PublicationDecade | 2000 |
| PublicationPlace | Hoboken |
| PublicationPlace_xml | – name: Hoboken – name: United States |
| PublicationTitle | Journal of neuroscience research |
| PublicationTitleAlternate | J. Neurosci. Res |
| PublicationYear | 2006 |
| Publisher | Wiley Subscription Services, Inc., A Wiley Company |
| Publisher_xml | – name: Wiley Subscription Services, Inc., A Wiley Company |
| References | Jacobs SC, Bootsma AL, Willems PW, Bar PR, Wokke JH. 1996. Prednisone can protect against exercise-induced muscle damage. J Neurol 243: 410-416. Gensert JM, Goldman JE. 1997. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 9: 197-203. Alonso G. 2000. Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and grey matter regions of the brain. Glia 31: 219-231. Franklin RJM, Crang AJ, Blakemore WF. 1991. Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord. J Neurocytol 20: 420-430. Rosner M, Lam TT, Fu J, Tso MO. 1992. Methylprednisolone ameliorates retinal photic injury in rats. Arch Ophthalmol 110: 857-861. Levine JM, Reynolds R. 1999. Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp Neurol 160: 333-347. Zivadinov R, Rudick RA, De Masi R, Nasuelli D, Ukmar M, Pozzi-Mucelli RS, Grop A, Cazzato G, Zorzon M. 2001. Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS. Neurology 57: 1239-1247. Edgar JM, McLaughlin M, Yool D, Zhang SC, Fowler JH, Montague P, Barrie JA, McCulloch MC, Duncan ID, Garbern J, Nave KA, Griffiths IR. 2004. Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. J Cell Biol 166: 121-131. Prineas JW, Barnard RO, Kwon EE, Sharer LR, Cho ES. 1993. Multiple sclerosis: remyelination of nascent lesions. Ann Neurol 33: 137-151. Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA. 1998. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280: 1610-1613. Rodriguez M, Lindsley MD. 1992. Immunosuppression promotes CNS remyelination in chronic virus-induced demyelinating disease. Neurology 42: 348-357. Russo-Marie F. 1992. Macrophages and the glucocorticoids. J Neuroimmunol 40: 281-286. Byravan S, Foster LM, Phan T, Verity AN, Campagnoni AT. 1994. Murine oligodendroglial cells express nerve growth factor. Proc Natl Acad Sci USA 91: 8812-8816. Franklin RJM. 2002. Why does remyelination fail in multiple sclerosis? Nat Rev Neurosci 3: 705-714. Smith KJ, Blakemore WF, McDonald WI. 1979. Central remyelination restores secure conduction. Nature 280: 395-396. Warringa RA, Hoeben RC, Koper JW, Sykes JE, van Golde LM, Lopes-Cardozo M. 1987. Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures. Brain Res 431: 79-86. Garbern JY, Yool DA, Moore GJ, Wilds IB, Faulk MW, Klugmann M, Nave KA, Sistermans EA, van der Knaap MS, Bird TD, Shy ME, Kamholz JA, Griffiths IR. 2002. Patients lacking the major CNS myelin protein,proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation. Brain 125: 551-561. Husemann J, Loike JD, Anankov R, Febbraio M, Silverstein SC. 2002. Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 40: 195-205. Trapp BD, Peterson J, Ransohoff RM, Rudick R. 1998. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338: 278-285. Lassmann H, Bruck W, Lucchinetti C, Rodriguez M. 1997. Remyelination in multiple sclerosis. Mult Scler 3: 133-136. Poduslo SE, Pak CH, Miller K. 1990. Hydrocortisone induction during oligodendroglial differentiation. Neurosci Lett 113: 84-88. Halfpenny CA, Scolding NJ. 2003. Immune-modifying agents do not impair the survival, migration or proliferation of oligodendrocyte progenitors (CG-4) in vitro. J Neuroimmunol 139: 9-16. Quinlivan JA, Beazley LD, Archer M, Beazley LD, Newnham JP. 1997. Repeated prenatal corticosteroids delay myelination in the ovine central nervous system. J Matern Fetal Med 6: 309-313. Graca DL, Blakemore WF. 1986. Delayed remyelination in the rat spinal cord following ethidium bromide injection. Neuropathol Appl Neurobiol 12: 593-605. Jeffery ND, Blakemore WF. 1997. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain 120: 27-37. Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, Linington C, Schmidbauer M, Lassmann H. 2000. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active,inactive, and remyelinated lesions. Am J Pathol 157: 267-276. Lovas G, Szilagyi N, Majtenyi K, Palkovits M, Komoly S. 2000. Axonal changes in chronically demyelinated cervical spinal cord plaques. Brain 123: 308-317. Triarhou LC, Herndon RM. 1986. The effect of dexamethasone on L-alpha-lysophosphatidyl choline (lysolecithin)-induced demyelination of the rat spinal cord. Arch Neurol 43: 121-125. Redwine JM, Armstrong RC. 1998. In vivo proliferation of oligodendrocyte progenitors expressing PDGF alphaR during early remyelination. J Neurobiol 37: 413-428. Blakemore WF, Chari DM, Gilson JM, Crang AJ. 2002. Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS. Glia 38: 155-168. Watanabe M, Toyama Y, Nishiyama A. 2002. Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion. J Neurosci Res 69: 826-836. Han J, Hajjar DP, Febbraio M, Nicholson AC. 1997. Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36. J Biol Chem 272: 21654-21659. Keegan BM, Noseworthy JH. 2002. Multiple sclerosis. Annu Rev Med 53: 285-302. Sim FJ, Zhao C, Li WW, Lakatos A, Franklin RJM. 2002. Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. Mol Cell Neurosci 20: 669-682. Bohn MC, Friedrich VL. 1982. Recovery of myelination in rat optic nerve after developmental retardation by cortisol. J Neurosci 2: 1292-1298. Huang WL, Harper CG, Evans SF, Newnham JP, Dunlop SA. 2001. Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep. Int J Dev Neurosci 19: 415-425. Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJM. 2001. Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 35: 204-212. Leussink VI, Jung S, Merschdorf U, Toyka KV, Gold R. 2001. High dose methylprednisolone therapy induces apoptosis in peripheral blood leukocytes. Arch Neurol 58: 91-97. Frost EE, Nielsen JA, Le TQ, Armstrong RC. 2003. PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination. J Neurobiol 54: 457-472. Glezer I, Rivest S. 2004. Glucocorticoids: protectors of the brain during innate immune responses. Neuroscientist 10: 538-552. Melcangi RC, Cavaretta I, Magnaghi V, Ciusani E, Salmaggi A. 2000. Corticosteroids protect oligodendrocytes from cytokine induced cell death. Neuroreport 11: 3969-3972. Gonzalez-Perez O, Ramos-Remus C, Garcia-Estrada J, Luquin S. 2001. Prednisone induces anxiety and glial cerebral changes in rats. J Rheumatol 28: 2529-2534. Miller DH, Thompson AG, Morrissey SP, MacManus DG, Moore SG, Kendall BE, Moseley IF, McDonald WI. 1992. High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effects. J Neurol Neurosurg Psychiatry 55: 450-453. Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP. 2001. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4: 1116-1122. Li WW, Setzu A, Zhao C, Franklin RJM. 2005. Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination. J Neuroimmunol 158: 58-66. Mason JL, Suzuki K, Chaplin DD, Matsushima GK. 2001. Interleukin-1beta promotes repair of the CNS. J Neurosci 21: 7046-7052. Pavelko KD, van Engelen BG, Rodriguez M. 1998. Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination. J Neurosci 18: 2498-2505. Ferguson B, Matyszak MK, Esiri MM, Perry VH. 1997. Axonal damage in multiple sclerosis lesions. Brain 120: 393-399. Arnett HA, Wang Y, Matsushima GK, Suzuki K, Ting JP. 2003. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23: 9824-9832. Neuberger TJ, Kalimi O, Regelson W, Kalimi M, De Vries GH. 1994. Glucocorticoids enhance the potency of Schwann cell mitogens. J Neurosci Res 15: 300-313. Husemann J, Silverstein SC. 2001. Expression of scavenger receptor class B,type 1, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's diseased brain. Am J Pathol 158: 825-832. Prineas JW, Connell F. 1979. Remyelination in multiple sclerosis. Ann Neurol 5: 22-31. Ludwin SK. 1980. Chronic demyelination inhibits remyelination in the central nervous system. Lab Invest 43: 382-387. Blakemore WF. 2005. The case for a central nervous system (CNS) origin for the Schwann cells that remyelinate CNS axons following concurrent loss of oligodendrocytes and astrocytes. Neuropathol Appl Neurobiol 31: 1-10. Raine CS, Wu E. 1993. Multiple sclerosis: remyelination in acute lesions. J Neuropathol Exp Neurol 52: 199-204. Smith PM, Franklin RJM. 2001. The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination. J Neuroimmunol 119: 261-268. Ayers MM, Hazelwood LJ, Catmull DV, Wang D, McKormack Q, Bernard CC, Orian JM. 2004. Early glial responses in murine models of multiple sclerosis. Neurochem Int 45: 409-419. Kotter MR, Zhao C, van Rooijen N, Franklin RJM. 2005. Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell respo 2004; 166 1998; 280 1985; 29 2004; 126 2002; 53 1997; 272 1980; 43 1997; 6 1997; 3 1992; 55 2003; 53 1997; 9 2003; 54 1998; 18 1987; 431 2000; 16 1982; 2 1992; 110 1986; 43 2002; 40 1993; 33 2000; 11 1999; 14 2001; 19 1979; 5 2005; 31 2000; 123 1992; 42 1998; 95 2001; 57 2001; 58 1992; 40 1979; 280 2002; 38 2003; 139 2000; 157 1986; 12 2005; 158 2004; 45 1998; 338 2002; 3 2006 1996; 243 2001; 28 1999; 5 2001; 21 2004; 10 1998; 37 2002; 69 2002; 20 2001; 4 1997; 120 1999; 160 1994; 120 1991; 20 2002; 125 2000; 31 1993; 52 2003; 184 1994; 12 1994; 15 2001; 119 1994; 91 1990; 113 2001; 35 2005; 18 2001; 158 2003; 23 Griffiths (10.1002/jnr.20763-BIB26) 1998; 280 Neuberger (10.1002/jnr.20763-BIB51) 1994; 15 Raine (10.1002/jnr.20763-BIB57) 1993; 52 Arnett (10.1002/jnr.20763-BIB3) 2003; 23 Rosner (10.1002/jnr.20763-BIB60) 1992; 110 Triarhou (10.1002/jnr.20763-BIB66) 1986; 43 Kotter (10.1002/jnr.20763-BIB40) 2005; 18 Chan (10.1002/jnr.20763-BIB13) 1998; 95 Kotter (10.1002/jnr.20763-BIB39) 2001; 35 Pavelko (10.1002/jnr.20763-BIB52) 1998; 18 Feldhaus (10.1002/jnr.20763-BIB15) 2004; 126 Glezer (10.1002/jnr.20763-BIB23) 2004; 10 Franklin (10.1002/jnr.20763-BIB19) 1991; 20 Arnett (10.1002/jnr.20763-BIB2) 2001; 4 Bohn (10.1002/jnr.20763-BIB10) 1982; 2 Hinks (10.1002/jnr.20763-BIB30) 1999; 14 Ayers (10.1002/jnr.20763-BIB4) 2004; 45 Russo-Marie (10.1002/jnr.20763-BIB61) 1992; 40 Prineas (10.1002/jnr.20763-BIB54) 1993; 33 Byravan (10.1002/jnr.20763-BIB11) 1994; 12 Redwine (10.1002/jnr.20763-BIB58) 1998; 37 Melcangi (10.1002/jnr.20763-BIB49) 2000; 11 Mason (10.1002/jnr.20763-BIB48) 2001; 21 Edgar (10.1002/jnr.20763-BIB14) 2004; 166 Graca (10.1002/jnr.20763-BIB25) 1986; 12 Alonso (10.1002/jnr.20763-BIB1) 2000; 31 Han (10.1002/jnr.20763-BIB28) 1997; 272 Blakemore (10.1002/jnr.20763-BIB7) 2005; 31 Gensert (10.1002/jnr.20763-BIB22) 1997; 9 Halfpenny (10.1002/jnr.20763-BIB27) 2003; 139 Byravan (10.1002/jnr.20763-BIB12) 1994; 91 Sim (10.1002/jnr.20763-BIB62) 2002; 20 Smith (10.1002/jnr.20763-BIB64) 2001; 119 Trapp (10.1002/jnr.20763-BIB65) 1998; 338 Garbern (10.1002/jnr.20763-BIB21) 2002; 125 Leussink (10.1002/jnr.20763-BIB42) 2001; 58 Li (10.1002/jnr.20763-BIB44) 2005; 158 Blakemore (10.1002/jnr.20763-BIB9) 2003; 184 Franklin (10.1002/jnr.20763-BIB17) 1999; 5 Jeffery (10.1002/jnr.20763-BIB36) 1997; 120 Lassmann (10.1002/jnr.20763-BIB41) 1997; 3 Poduslo (10.1002/jnr.20763-BIB53) 1990; 113 Rodriguez (10.1002/jnr.20763-BIB59) 1992; 42 Gonzalez-Perez (10.1002/jnr.20763-BIB24) 2001; 28 Blakemore (10.1002/jnr.20763-BIB8) 2002; 38 Zhao (10.1002/jnr.20763-BIB70) 2006 Barres (10.1002/jnr.20763-BIB5) 1994; 120 Hemmer (10.1002/jnr.20763-BIB29) 2002; 3 Jacobs (10.1002/jnr.20763-BIB35) 1996; 243 Zivadinov (10.1002/jnr.20763-BIB71) 2001; 57 Long (10.1002/jnr.20763-BIB45) 1985; 29 Lovas (10.1002/jnr.20763-BIB46) 2000; 123 Ludwin (10.1002/jnr.20763-BIB47) 1980; 43 Miller (10.1002/jnr.20763-BIB50) 1992; 55 Husemann (10.1002/jnr.20763-BIB34) 2001; 158 Huang (10.1002/jnr.20763-BIB32) 2001; 19 Smith (10.1002/jnr.20763-BIB63) 1979; 280 Frost (10.1002/jnr.20763-BIB20) 2003; 54 Hinks (10.1002/jnr.20763-BIB31) 2000; 16 Franklin (10.1002/jnr.20763-BIB18) 2002; 3 Kornek (10.1002/jnr.20763-BIB38) 2000; 157 Levine (10.1002/jnr.20763-BIB43) 1999; 160 Keegan (10.1002/jnr.20763-BIB37) 2002; 53 Prineas (10.1002/jnr.20763-BIB55) 1979; 5 Watanabe (10.1002/jnr.20763-BIB68) 2002; 69 Wilkins (10.1002/jnr.20763-BIB69) 2003; 23 Husemann (10.1002/jnr.20763-BIB33) 2002; 40 Bieber (10.1002/jnr.20763-BIB6) 2003; 53 Ferguson (10.1002/jnr.20763-BIB16) 1997; 120 Quinlivan (10.1002/jnr.20763-BIB56) 1997; 6 Warringa (10.1002/jnr.20763-BIB67) 1987; 431 |
| References_xml | – volume: 54 start-page: 457 year: 2003 end-page: 472 article-title: PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination publication-title: J Neurobiol – volume: 38 start-page: 155 year: 2002 end-page: 168 article-title: Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS publication-title: Glia – volume: 158 start-page: 825 year: 2001 end-page: 832 article-title: Expression of scavenger receptor class B,type 1, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's diseased brain publication-title: Am J Pathol – volume: 55 start-page: 450 year: 1992 end-page: 453 article-title: High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effects publication-title: J Neurol Neurosurg Psychiatry – volume: 3 start-page: 133 year: 1997 end-page: 136 article-title: Remyelination in multiple sclerosis publication-title: Mult Scler – volume: 53 start-page: 680 year: 2003 end-page: 684 article-title: Efficient central nervous system remyelination requires T cells publication-title: Ann Neurol – volume: 4 start-page: 1116 year: 2001 end-page: 1122 article-title: TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination publication-title: Nat Neurosci – volume: 12 start-page: 343 year: 1994 end-page: 351 article-title: Serum factors and hydrocortisone influence the synthesis of myelin basic proteins in mouse brain primary cultures publication-title: Int J Dev Neurosci – volume: 16 start-page: 542 year: 2000 end-page: 556 article-title: Delayed changes in growth factor gene expression during slow remyelination in the CNS of aged rats publication-title: Mol Cell Neurosci – volume: 69 start-page: 826 year: 2002 end-page: 836 article-title: Differentiation of proliferated NG2‐positive glial progenitor cells in a remyelinating lesion publication-title: J Neurosci Res – volume: 31 start-page: 1 year: 2005 end-page: 10 article-title: The case for a central nervous system (CNS) origin for the Schwann cells that remyelinate CNS axons following concurrent loss of oligodendrocytes and astrocytes publication-title: Neuropathol Appl Neurobiol – volume: 2 start-page: 1292 year: 1982 end-page: 1298 article-title: Recovery of myelination in rat optic nerve after developmental retardation by cortisol publication-title: J Neurosci – volume: 5 start-page: 22 year: 1979 end-page: 31 article-title: Remyelination in multiple sclerosis publication-title: Ann Neurol – volume: 23 start-page: 9824 year: 2003 end-page: 9832 article-title: Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration publication-title: J Neurosci – volume: 6 start-page: 309 year: 1997 end-page: 313 article-title: Repeated prenatal corticosteroids delay myelination in the ovine central nervous system publication-title: J Matern Fetal Med – volume: 37 start-page: 413 year: 1998 end-page: 428 article-title: In vivo proliferation of oligodendrocyte progenitors expressing PDGF alphaR during early remyelination publication-title: J Neurobiol – volume: 12 start-page: 593 year: 1986 end-page: 605 article-title: Delayed remyelination in the rat spinal cord following ethidium bromide injection publication-title: Neuropathol Appl Neurobiol – volume: 3 start-page: 705 year: 2002 end-page: 714 article-title: Why does remyelination fail in multiple sclerosis? publication-title: Nat Rev Neurosci – volume: 243 start-page: 410 year: 1996 end-page: 416 article-title: Prednisone can protect against exercise‐induced muscle damage publication-title: J Neurol – volume: 43 start-page: 382 year: 1980 end-page: 387 article-title: Chronic demyelination inhibits remyelination in the central nervous system publication-title: Lab Invest – volume: 110 start-page: 857 year: 1992 end-page: 861 article-title: Methylprednisolone ameliorates retinal photic injury in rats publication-title: Arch Ophthalmol – volume: 43 start-page: 121 year: 1986 end-page: 125 article-title: The effect of dexamethasone on L‐alpha‐lysophosphatidyl choline (lysolecithin)‐induced demyelination of the rat spinal cord publication-title: Arch Neurol – volume: 431 start-page: 79 year: 1987 end-page: 86 article-title: Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures publication-title: Brain Res – volume: 157 start-page: 267 year: 2000 end-page: 276 article-title: Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active,inactive, and remyelinated lesions publication-title: Am J Pathol – volume: 20 start-page: 420 year: 1991 end-page: 430 article-title: Transplanted type‐1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord publication-title: J Neurocytol – volume: 272 start-page: 21654 year: 1997 end-page: 21659 article-title: Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36 publication-title: J Biol Chem – volume: 57 start-page: 1239 year: 2001 end-page: 1247 article-title: Effects of IV methylprednisolone on brain atrophy in relapsing‐remitting MS publication-title: Neurology – volume: 95 start-page: 10459 year: 1998 end-page: 10464 article-title: Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation publication-title: Proc Natl Acad Sci USA – volume: 126 start-page: 282 year: 2004 end-page: 285 article-title: Corticoids protect oligodendrocyte precursor cells against cytokine‐induced damage publication-title: Zentralbl Gynakol – volume: 280 start-page: 1610 year: 1998 end-page: 1613 article-title: Axonal swellings and degeneration in mice lacking the major proteolipid of myelin publication-title: Science – volume: 33 start-page: 137 year: 1993 end-page: 151 article-title: Multiple sclerosis: remyelination of nascent lesions publication-title: Ann Neurol – volume: 18 start-page: 166 year: 2005 end-page: 175 article-title: Macrophage‐depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression publication-title: Neurobiol Dis – volume: 28 start-page: 2529 year: 2001 end-page: 2534 article-title: Prednisone induces anxiety and glial cerebral changes in rats publication-title: J Rheumatol – volume: 338 start-page: 278 year: 1998 end-page: 285 article-title: Axonal transection in the lesions of multiple sclerosis publication-title: N Engl J Med – volume: 184 start-page: 955 year: 2003 end-page: 963 article-title: The presence of astrocytes in areas of demyelination influences remyelination following transplantation of oligodendrocyte progenitors publication-title: Exp Neurol – volume: 18 start-page: 2498 year: 1998 end-page: 2505 article-title: Acceleration in the rate of CNS remyelination in lysolecithin‐induced demyelination publication-title: J Neurosci – volume: 14 start-page: 153 year: 1999 end-page: 168 article-title: Distinctive patterns of PDGF‐A, FGF‐2, IGF‐I, and TGF‐beta1 gene expression during remyelination of experimentally‐induced spinal cord demyelination publication-title: Mol Cell Neurosci – volume: 58 start-page: 91 year: 2001 end-page: 97 article-title: High dose methylprednisolone therapy induces apoptosis in peripheral blood leukocytes publication-title: Arch Neurol – volume: 120 start-page: 1097 year: 1994 end-page: 1108 article-title: A novel role for thyroid hormone,glucocorticoids and retinoic acid in timing oligodendrocyte development publication-title: Development – volume: 19 start-page: 415 year: 2001 end-page: 425 article-title: Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep publication-title: Int J Dev Neurosci – volume: 20 start-page: 669 year: 2002 end-page: 682 article-title: Expression of the POU‐domain transcription factors SCIP/Oct‐6 and Brn‐2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS publication-title: Mol Cell Neurosci – volume: 3 start-page: 291 year: 2002 end-page: 301 article-title: New concepts in the immunopathogenesis of multiple sclerosis publication-title: Nat Rev Neurosci – volume: 123 start-page: 308 year: 2000 end-page: 317 article-title: Axonal changes in chronically demyelinated cervical spinal cord plaques publication-title: Brain – volume: 113 start-page: 84 year: 1990 end-page: 88 article-title: Hydrocortisone induction during oligodendroglial differentiation publication-title: Neurosci Lett – volume: 158 start-page: 58 year: 2005 end-page: 66 article-title: Minocycline‐mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non‐immune model of demyelination publication-title: J Neuroimmunol – volume: 119 start-page: 261 year: 2001 end-page: 268 article-title: The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin‐induced demyelination publication-title: J Neuroimmunol – volume: 35 start-page: 204 year: 2001 end-page: 212 article-title: Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin‐induced demyelination publication-title: Glia – volume: 280 start-page: 395 year: 1979 end-page: 396 article-title: Central remyelination restores secure conduction publication-title: Nature – volume: 23 start-page: 4967 year: 2003 end-page: 4974 article-title: Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte‐derived glial cell line‐derived neurotrophic factor publication-title: J Neurosci – volume: 120 start-page: 27 year: 1997 end-page: 37 article-title: Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination publication-title: Brain – volume: 9 start-page: 197 year: 1997 end-page: 203 article-title: Endogenous progenitors remyelinate demyelinated axons in the adult CNS publication-title: Neuron – volume: 29 start-page: 1580 year: 1985 end-page: 1583 article-title: Blood‐brain barrier: endogenous modulation by adrenal‐cortical function publication-title: Science – volume: 11 start-page: 3969 year: 2000 end-page: 3972 article-title: Corticosteroids protect oligodendrocytes from cytokine induced cell death publication-title: Neuroreport – volume: 5 start-page: 184 year: 1999 end-page: 191 article-title: Remyelination—a regenerative process in the CNS publication-title: Neuroscientist – volume: 52 start-page: 199 year: 1993 end-page: 204 article-title: Multiple sclerosis: remyelination in acute lesions publication-title: J Neuropathol Exp Neurol – volume: 166 start-page: 121 year: 2004 end-page: 131 article-title: Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia publication-title: J Cell Biol – volume: 15 start-page: 300 year: 1994 end-page: 313 article-title: Glucocorticoids enhance the potency of Schwann cell mitogens publication-title: J Neurosci Res – volume: 21 start-page: 7046 year: 2001 end-page: 7052 article-title: Interleukin‐1beta promotes repair of the CNS publication-title: J Neurosci – volume: 45 start-page: 409 year: 2004 end-page: 419 article-title: Early glial responses in murine models of multiple sclerosis publication-title: Neurochem Int – volume: 125 start-page: 551 year: 2002 end-page: 561 article-title: Patients lacking the major CNS myelin protein,proteolipid protein 1, develop length‐dependent axonal degeneration in the absence of demyelination and inflammation publication-title: Brain – volume: 31 start-page: 219 year: 2000 end-page: 231 article-title: Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and grey matter regions of the brain publication-title: Glia – volume: 40 start-page: 281 year: 1992 end-page: 286 article-title: Macrophages and the glucocorticoids publication-title: J Neuroimmunol – volume: 40 start-page: 195 year: 2002 end-page: 205 article-title: Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system publication-title: Glia – volume: 91 start-page: 8812 year: 1994 end-page: 8816 article-title: Murine oligodendroglial cells express nerve growth factor publication-title: Proc Natl Acad Sci USA – volume: 42 start-page: 348 year: 1992 end-page: 357 article-title: Immunosuppression promotes CNS remyelination in chronic virus‐induced demyelinating disease publication-title: Neurology – volume: 10 start-page: 538 year: 2004 end-page: 552 article-title: Glucocorticoids: protectors of the brain during innate immune responses publication-title: Neuroscientist – volume: 139 start-page: 9 year: 2003 end-page: 16 article-title: Immune‐modifying agents do not impair the survival, migration or proliferation of oligodendrocyte progenitors (CG‐4) in vitro publication-title: J Neuroimmunol – volume: 120 start-page: 393 year: 1997 end-page: 399 article-title: Axonal damage in multiple sclerosis lesions publication-title: Brain – year: 2006 article-title: Differences in the early inflammatory responses to toxin induced demyelination are associated with age related decline in CNS remyelination publication-title: Neurobiol Aging – volume: 160 start-page: 333 year: 1999 end-page: 347 article-title: Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide‐induced demyelination publication-title: Exp Neurol – volume: 53 start-page: 285 year: 2002 end-page: 302 article-title: Multiple sclerosis publication-title: Annu Rev Med – volume: 91 start-page: 8812 year: 1994 ident: 10.1002/jnr.20763-BIB12 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.91.19.8812 contributor: fullname: Byravan – volume: 123 start-page: 308 year: 2000 ident: 10.1002/jnr.20763-BIB46 publication-title: Brain doi: 10.1093/brain/123.2.308 contributor: fullname: Lovas – volume: 55 start-page: 450 year: 1992 ident: 10.1002/jnr.20763-BIB50 publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.55.6.450 contributor: fullname: Miller – volume: 20 start-page: 669 year: 2002 ident: 10.1002/jnr.20763-BIB62 publication-title: Mol Cell Neurosci doi: 10.1006/mcne.2002.1145 contributor: fullname: Sim – volume: 28 start-page: 2529 year: 2001 ident: 10.1002/jnr.20763-BIB24 publication-title: J Rheumatol contributor: fullname: Gonzalez-Perez – volume: 160 start-page: 333 year: 1999 ident: 10.1002/jnr.20763-BIB43 publication-title: Exp Neurol doi: 10.1006/exnr.1999.7224 contributor: fullname: Levine – volume: 43 start-page: 121 year: 1986 ident: 10.1002/jnr.20763-BIB66 publication-title: Arch Neurol doi: 10.1001/archneur.1986.00520020015008 contributor: fullname: Triarhou – volume: 5 start-page: 184 year: 1999 ident: 10.1002/jnr.20763-BIB17 publication-title: Neuroscientist doi: 10.1177/107385849900500315 contributor: fullname: Franklin – volume: 12 start-page: 343 year: 1994 ident: 10.1002/jnr.20763-BIB11 publication-title: Int J Dev Neurosci doi: 10.1016/0736-5748(94)90084-1 contributor: fullname: Byravan – volume: 35 start-page: 204 year: 2001 ident: 10.1002/jnr.20763-BIB39 publication-title: Glia doi: 10.1002/glia.1085 contributor: fullname: Kotter – volume: 158 start-page: 825 year: 2001 ident: 10.1002/jnr.20763-BIB34 publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64030-8 contributor: fullname: Husemann – volume: 58 start-page: 91 year: 2001 ident: 10.1002/jnr.20763-BIB42 publication-title: Arch Neurol doi: 10.1001/archneur.58.1.91 contributor: fullname: Leussink – volume: 338 start-page: 278 year: 1998 ident: 10.1002/jnr.20763-BIB65 publication-title: N Engl J Med doi: 10.1056/NEJM199801293380502 contributor: fullname: Trapp – volume: 19 start-page: 415 year: 2001 ident: 10.1002/jnr.20763-BIB32 publication-title: Int J Dev Neurosci doi: 10.1016/S0736-5748(01)00026-0 contributor: fullname: Huang – volume: 3 start-page: 705 year: 2002 ident: 10.1002/jnr.20763-BIB18 publication-title: Nat Rev Neurosci doi: 10.1038/nrn917 contributor: fullname: Franklin – volume: 5 start-page: 22 year: 1979 ident: 10.1002/jnr.20763-BIB55 publication-title: Ann Neurol doi: 10.1002/ana.410050105 contributor: fullname: Prineas – volume: 54 start-page: 457 year: 2003 ident: 10.1002/jnr.20763-BIB20 publication-title: J Neurobiol doi: 10.1002/neu.10158 contributor: fullname: Frost – volume: 42 start-page: 348 year: 1992 ident: 10.1002/jnr.20763-BIB59 publication-title: Neurology doi: 10.1212/WNL.42.2.348 contributor: fullname: Rodriguez – volume: 57 start-page: 1239 year: 2001 ident: 10.1002/jnr.20763-BIB71 publication-title: Neurology doi: 10.1212/WNL.57.7.1239 contributor: fullname: Zivadinov – volume: 21 start-page: 7046 year: 2001 ident: 10.1002/jnr.20763-BIB48 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-18-07046.2001 contributor: fullname: Mason – volume: 53 start-page: 285 year: 2002 ident: 10.1002/jnr.20763-BIB37 publication-title: Annu Rev Med doi: 10.1146/annurev.med.53.082901.103909 contributor: fullname: Keegan – volume: 272 start-page: 21654 year: 1997 ident: 10.1002/jnr.20763-BIB28 publication-title: J Biol Chem doi: 10.1074/jbc.272.34.21654 contributor: fullname: Han – volume: 9 start-page: 197 year: 1997 ident: 10.1002/jnr.20763-BIB22 publication-title: Neuron doi: 10.1016/S0896-6273(00)80359-1 contributor: fullname: Gensert – volume: 120 start-page: 1097 year: 1994 ident: 10.1002/jnr.20763-BIB5 publication-title: Development doi: 10.1242/dev.120.5.1097 contributor: fullname: Barres – volume: 158 start-page: 58 year: 2005 ident: 10.1002/jnr.20763-BIB44 publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2004.08.011 contributor: fullname: Li – volume: 243 start-page: 410 year: 1996 ident: 10.1002/jnr.20763-BIB35 publication-title: J Neurol doi: 10.1007/BF00869001 contributor: fullname: Jacobs – volume: 15 start-page: 300 year: 1994 ident: 10.1002/jnr.20763-BIB51 publication-title: J Neurosci Res doi: 10.1002/jnr.490380308 contributor: fullname: Neuberger – volume: 157 start-page: 267 year: 2000 ident: 10.1002/jnr.20763-BIB38 publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64537-3 contributor: fullname: Kornek – volume: 280 start-page: 395 year: 1979 ident: 10.1002/jnr.20763-BIB63 publication-title: Nature doi: 10.1038/280395a0 contributor: fullname: Smith – volume: 29 start-page: 1580 year: 1985 ident: 10.1002/jnr.20763-BIB45 publication-title: Science doi: 10.1126/science.3975627 contributor: fullname: Long – volume: 110 start-page: 857 year: 1992 ident: 10.1002/jnr.20763-BIB60 publication-title: Arch Ophthalmol doi: 10.1001/archopht.1992.01080180129040 contributor: fullname: Rosner – volume: 139 start-page: 9 year: 2003 ident: 10.1002/jnr.20763-BIB27 publication-title: J Neuroimmunol doi: 10.1016/S0165-5728(03)00125-5 contributor: fullname: Halfpenny – volume: 2 start-page: 1292 year: 1982 ident: 10.1002/jnr.20763-BIB10 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.02-09-01292.1982 contributor: fullname: Bohn – volume: 69 start-page: 826 year: 2002 ident: 10.1002/jnr.20763-BIB68 publication-title: J Neurosci Res doi: 10.1002/jnr.10338 contributor: fullname: Watanabe – volume: 113 start-page: 84 year: 1990 ident: 10.1002/jnr.20763-BIB53 publication-title: Neurosci Lett doi: 10.1016/0304-3940(90)90499-Y contributor: fullname: Poduslo – volume: 45 start-page: 409 year: 2004 ident: 10.1002/jnr.20763-BIB4 publication-title: Neurochem Int doi: 10.1016/j.neuint.2003.08.018 contributor: fullname: Ayers – volume: 20 start-page: 420 year: 1991 ident: 10.1002/jnr.20763-BIB19 publication-title: J Neurocytol doi: 10.1007/BF01355538 contributor: fullname: Franklin – volume: 40 start-page: 195 year: 2002 ident: 10.1002/jnr.20763-BIB33 publication-title: Glia doi: 10.1002/glia.10148 contributor: fullname: Husemann – volume: 37 start-page: 413 year: 1998 ident: 10.1002/jnr.20763-BIB58 publication-title: J Neurobiol doi: 10.1002/(SICI)1097-4695(19981115)37:3<413::AID-NEU7>3.0.CO;2-8 contributor: fullname: Redwine – volume: 10 start-page: 538 year: 2004 ident: 10.1002/jnr.20763-BIB23 publication-title: Neuroscientist doi: 10.1177/1073858404263494 contributor: fullname: Glezer – volume: 40 start-page: 281 year: 1992 ident: 10.1002/jnr.20763-BIB61 publication-title: J Neuroimmunol doi: 10.1016/0165-5728(92)90144-A contributor: fullname: Russo-Marie – volume: 166 start-page: 121 year: 2004 ident: 10.1002/jnr.20763-BIB14 publication-title: J Cell Biol doi: 10.1083/jcb.200312012 contributor: fullname: Edgar – volume: 31 start-page: 1 year: 2005 ident: 10.1002/jnr.20763-BIB7 publication-title: Neuropathol Appl Neurobiol doi: 10.1111/j.1365-2990.2005.00637.x contributor: fullname: Blakemore – volume: 16 start-page: 542 year: 2000 ident: 10.1002/jnr.20763-BIB31 publication-title: Mol Cell Neurosci doi: 10.1006/mcne.2000.0897 contributor: fullname: Hinks – volume: 280 start-page: 1610 year: 1998 ident: 10.1002/jnr.20763-BIB26 publication-title: Science doi: 10.1126/science.280.5369.1610 contributor: fullname: Griffiths – volume: 119 start-page: 261 year: 2001 ident: 10.1002/jnr.20763-BIB64 publication-title: J Neuroimmunol doi: 10.1016/S0165-5728(01)00396-4 contributor: fullname: Smith – volume: 4 start-page: 1116 year: 2001 ident: 10.1002/jnr.20763-BIB2 publication-title: Nat Neurosci doi: 10.1038/nn738 contributor: fullname: Arnett – volume: 38 start-page: 155 year: 2002 ident: 10.1002/jnr.20763-BIB8 publication-title: Glia doi: 10.1002/glia.10067 contributor: fullname: Blakemore – volume: 184 start-page: 955 year: 2003 ident: 10.1002/jnr.20763-BIB9 publication-title: Exp Neurol doi: 10.1016/S0014-4886(03)00347-9 contributor: fullname: Blakemore – volume: 126 start-page: 282 year: 2004 ident: 10.1002/jnr.20763-BIB15 publication-title: Zentralbl Gynakol doi: 10.1055/s-2004-822759 contributor: fullname: Feldhaus – volume: 33 start-page: 137 year: 1993 ident: 10.1002/jnr.20763-BIB54 publication-title: Ann Neurol doi: 10.1002/ana.410330203 contributor: fullname: Prineas – volume: 23 start-page: 4967 year: 2003 ident: 10.1002/jnr.20763-BIB69 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-12-04967.2003 contributor: fullname: Wilkins – volume: 23 start-page: 9824 year: 2003 ident: 10.1002/jnr.20763-BIB3 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-30-09824.2003 contributor: fullname: Arnett – year: 2006 ident: 10.1002/jnr.20763-BIB70 publication-title: Neurobiol Aging contributor: fullname: Zhao – volume: 95 start-page: 10459 year: 1998 ident: 10.1002/jnr.20763-BIB13 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.95.18.10459 contributor: fullname: Chan – volume: 120 start-page: 393 year: 1997 ident: 10.1002/jnr.20763-BIB16 publication-title: Brain doi: 10.1093/brain/120.3.393 contributor: fullname: Ferguson – volume: 52 start-page: 199 year: 1993 ident: 10.1002/jnr.20763-BIB57 publication-title: J Neuropathol Exp Neurol doi: 10.1097/00005072-199305000-00003 contributor: fullname: Raine – volume: 11 start-page: 3969 year: 2000 ident: 10.1002/jnr.20763-BIB49 publication-title: Neuroreport doi: 10.1097/00001756-200012180-00013 contributor: fullname: Melcangi – volume: 18 start-page: 2498 year: 1998 ident: 10.1002/jnr.20763-BIB52 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.18-07-02498.1998 contributor: fullname: Pavelko – volume: 125 start-page: 551 year: 2002 ident: 10.1002/jnr.20763-BIB21 publication-title: Brain doi: 10.1093/brain/awf043 contributor: fullname: Garbern – volume: 6 start-page: 309 year: 1997 ident: 10.1002/jnr.20763-BIB56 publication-title: J Matern Fetal Med contributor: fullname: Quinlivan – volume: 31 start-page: 219 year: 2000 ident: 10.1002/jnr.20763-BIB1 publication-title: Glia doi: 10.1002/1098-1136(200009)31:3<219::AID-GLIA30>3.0.CO;2-R contributor: fullname: Alonso – volume: 3 start-page: 291 year: 2002 ident: 10.1002/jnr.20763-BIB29 publication-title: Nat Rev Neurosci doi: 10.1038/nrn784 contributor: fullname: Hemmer – volume: 53 start-page: 680 year: 2003 ident: 10.1002/jnr.20763-BIB6 publication-title: Ann Neurol doi: 10.1002/ana.10578 contributor: fullname: Bieber – volume: 18 start-page: 166 year: 2005 ident: 10.1002/jnr.20763-BIB40 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2004.09.019 contributor: fullname: Kotter – volume: 120 start-page: 27 year: 1997 ident: 10.1002/jnr.20763-BIB36 publication-title: Brain doi: 10.1093/brain/120.1.27 contributor: fullname: Jeffery – volume: 431 start-page: 79 year: 1987 ident: 10.1002/jnr.20763-BIB67 publication-title: Brain Res doi: 10.1016/0165-3806(87)90197-0 contributor: fullname: Warringa – volume: 12 start-page: 593 year: 1986 ident: 10.1002/jnr.20763-BIB25 publication-title: Neuropathol Appl Neurobiol doi: 10.1111/j.1365-2990.1986.tb00162.x contributor: fullname: Graca – volume: 3 start-page: 133 year: 1997 ident: 10.1002/jnr.20763-BIB41 publication-title: Mult Scler doi: 10.1177/135245859700300213 contributor: fullname: Lassmann – volume: 43 start-page: 382 year: 1980 ident: 10.1002/jnr.20763-BIB47 publication-title: Lab Invest contributor: fullname: Ludwin – volume: 14 start-page: 153 year: 1999 ident: 10.1002/jnr.20763-BIB30 publication-title: Mol Cell Neurosci doi: 10.1006/mcne.1999.0771 contributor: fullname: Hinks |
| SSID | ssj0009953 |
| Score | 2.099374 |
| Snippet | High dose corticosteroid (CS) administration is a common mode of therapy in treatment of acute relapses in multiple sclerosis (MS) but the effects of CS on... |
| SourceID | crossref pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 594 |
| SubjectTerms | Adrenal Cortex Hormones - pharmacology Animals Central Nervous System - drug effects Central Nervous System - pathology corticosteroids Demyelinating Diseases - chemically induced Demyelinating Diseases - pathology demyelination Ethidium Female Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry In Situ Hybridization Macrophages - drug effects multiple sclerosis Myelin Sheath - drug effects oligodendrocyte progenitors Oligodendroglia - drug effects Oligodendroglia - pathology Phagocytosis Rats remyelination Stem Cells - drug effects Stem Cells - pathology |
| Title | Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system |
| URI | https://api.istex.fr/ark:/67375/WNG-MQGQ159X-P/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjnr.20763 https://www.ncbi.nlm.nih.gov/pubmed/16429447 |
| Volume | 83 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ZSwMxEA5aX3zxqsd6EUSKL0t3k72CT6XWFsHSemDfwnaThSrdlV0L9t87SXo-CIJvuyR7kJnMzBdmvkHo2hGBZIKC8g4ptT2IeW0mfccm0qEAccHna3b9znPYHUR3LUWTczuvhTH8EIsDN7UztL1WGzwelvUlaeh7pug8YXuA_QWUoMs3aG9JuMsMAyUNHMBILpmzCjmkvnhyzRdtqWX9XnFEq8Gq9jb3u__6zz20MwsyccNoxT7akNkBqjYyANjjKa5hnfapz9OrKG3mapqq9SjykSixoo2c4kKOp6pUXQsO5ylebQWAxdroKMMQRmIwxTCKZ-meOAMrlE9KbLiiD9Hrfeul2bFnzRfshIKLtwVJWOoKSYOQiThSJDEpwI_ITX3i-UkkiJIxY0OwAnDrxcSJJXNV72LBfCLpEapkeSZPEA4CwiREkoHDIi-llMVhIgCmCeIlSRjGFrqai4F_Go4NbtiUCYfV43r1LFTTAlrMiIsPlZQW-vyt2-aP_XYfIrMB71no2Ehw-S7AWMzzQgvdaEH9_hH-0H3SF6d_n3qGts2xjMpLO0eVr2IiL9BmKSaXWiN_AL6W4V8 |
| link.rule.ids | 315,782,786,1408,27935,27936,46066,46490 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JSwMxFH64HPTiVpe6BhHxMnSaZJaAl1KtdStVK_YWppMMVHFGWgv23_uS6eZBELzNkDcLefvj5XsAJ67ytVAMhbfDmMMx5nWE9lyHapdhios-36Lr15-CRju8uDQwOefjszA5PsSk4GY0w9pro-CmIF2aooa-pgbPE_VjHha5z4UZ3MBYcwq5K3IMSua7mCWV6RhXyKWlyaM_vNGi2divGVc0G65af1Nb_d-frsHKKM4klVww1mFOpxtQqKSYY78PySmxnZ-2pF6ApJoZMnPco5d1VZ8Y5Mgh6en3oTmtbnlHsoTMTgMg6sdqNyUYSRK0xrhKRh2fJEVDlA36JIeL3oTn2mWrWndG8xecmKGXdxSNRVJWmvmBUFFocGISzEDCcuJR7sWhoobNQnTQEOAtj6gbaVE244uV8KhmW7CQZqneAeL7VGgMJn1XhDxhTERBrDBTU5THcRBERTge80F-5DAbMgdUphJ3T9rdK8Kp5dCEIuq9mb60wJMvjSt5_3D1gMFZWzaLsJ2zcPouTLME50ERziynfv-IvGk82ovdv5MewVK9dX8n764bt3uwnFdpTJvaPix89gb6AOb7anBoxfMb8MzlgA |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ZSwMxEB60gvjiVY96BpHiy-JuslfwqfTwLq0H-ha2myyouFtaC_bfO8n2fBAE33ZJ9iAzmfkmzHwDcGpLX3HJUHk7jFkuYl6LK8-2qLIZhrjo8w27_tVj0HwNa3VNk3MxroXJ-SEmB256Zxh7rTd4VybnU9LQ91TTeeL2WIQlV8NwXb_BWlPGXZ5TUDLfxiDJoWNaIZueTx6dc0ZLel2_ZzzRLFo17qax9q8fXYfVEcoklVwtNmBBpZtQrKQYYX8OSZmYvE9zoF6EpJrpabrYo5e9yT7RvJFD0lOfQ12rbiRHsoTM9gIgcm70LSWIIwnaYhwlo3xPkqIZygZ9kpNFb8Fzo_5UvbJG3ResmKGPtySNeeJIxfyAyyjULDEJxh-hk3jU9eJQUi1kzjtoBvDWjagdKe7o5sWSe1SxbSikWap2gfg-5QqhpG_z0E0Y41EQS4zTJHXjOAiiEpyMxSC6OcmGyOmUqcDVE2b1SlA2AprMiHofOist8MRL81Lcty_bCM1eRasEO7kEp-_CIIu7blCCMyOo3z8ibpoP5mLv71OPYblVa4i76-btPqzkRzQ6R-0ACl-9gTqExb4cHBnl_AFVJuQv |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Corticosteroids+delay+remyelination+of+experimental+demyelination+in+the+rodent+central+nervous+system&rft.jtitle=Journal+of+neuroscience+research&rft.au=Chari%2C+Divya+M.&rft.au=Zhao%2C+Chao&rft.au=Kotter%2C+Mark+R.&rft.au=Blakemore%2C+William+F.&rft.date=2006-03-01&rft.pub=Wiley+Subscription+Services%2C+Inc.%2C+A+Wiley+Company&rft.issn=0360-4012&rft.eissn=1097-4547&rft.volume=83&rft.issue=4&rft.spage=594&rft.epage=605&rft_id=info:doi/10.1002%2Fjnr.20763&rft.externalDBID=10.1002%252Fjnr.20763&rft.externalDocID=JNR20763 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0360-4012&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0360-4012&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0360-4012&client=summon |