Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells

Neurosteroids are important regulators of central nervous system function and may be involved in processes of neuronal cell survival. This study was undertaken to test the effect of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), pregnenolone (PGL), pregnenolone sulfate (PGLS)...

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Bibliographic Details
Published in:	Journal of neuroscience research Vol. 86; no. 6; pp. 1361 - 1370
Main Authors:	Leskiewicz, M., Regulska, M., Budziszewska, B., Jantas, D., Jaworska-Feil, L., Basta-Kaim, A., Kubera, M., Jagla, G., Nowak, W., Lason, W.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-05-2008
Subjects:	Apoptosis - drug effects Brain - drug effects Brain - pathology caspase-3 activity Cell Line, Tumor Dehydroepiandrosterone - pharmacology Dehydroepiandrosterone Sulfate - pharmacology Enzyme Inhibitors - toxicity Humans hydrogen peroxide Hydrogen Peroxide - toxicity L-Lactate Dehydrogenase - secretion lactate dehydrogenase Membrane Potential, Mitochondrial - drug effects mitochondrial membrane potential Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Nerve Degeneration - prevention & control Neuroblastoma - metabolism Neurons - drug effects Neurons - pathology neurosteroids Oxidants - toxicity Oxidative Stress - drug effects Phosphatidylinositol 3-Kinases - drug effects Phosphatidylinositol 3-Kinases - metabolism Pregnanolone - pharmacology Pregnenolone - pharmacology staurosporine Staurosporine - toxicity Steroids - pharmacology
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