LncRNAs: the good, the bad, and the unknown

Long non-coding RNAs (lncRNAs) are significant contributors in maintaining genomic integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying complexes in both and pathways, drawing them to specific genomic loci and influencing gene expression via DNA methylation, histone...

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Bibliographic Details
Published in:	Biochemistry and cell biology Vol. 102; no. 1; p. 9
Main Author:	Arunkumar, Ganesan
Format:	Journal Article
Language:	English
Published:	Canada 01-02-2024
Subjects:	Chromatin - genetics DNA Methylation Epigenesis, Genetic Humans Neoplasms - genetics Neoplasms - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism genome organization non-coding RNAs epigenetics LncRNAs
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Summary:	Long non-coding RNAs (lncRNAs) are significant contributors in maintaining genomic integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying complexes in both and pathways, drawing them to specific genomic loci and influencing gene expression via DNA methylation, histone modifications, and chromatin remodeling. They can also operate as building blocks to assemble different chromatin-modifying components, facilitating their interactions and gene regulatory functions. Deregulation of these molecules has been associated with various human diseases, including cancer, cardiovascular disease, and neurological disorders. Thus, lncRNAs are implicated as potential diagnostic indicators and therapeutic targets. This review discusses the current understanding of how lncRNAs mediate epigenetic control, genomic integrity, and their putative functions in disease pathogenesis.
ISSN:	1208-6002
DOI:	10.1139/bcb-2023-0155