Allogeneic dendritic cells fused with tumor cells: preclinical results and outcome of a clinical phase I/II trial in patients with metastatic renal cell carcinoma

Therapeutic vaccination with dendritic cells (DC) can lead to tumor regression in animal models and has shown promising results in the first clinical trials of metastatic renal cell carcinoma and malignant melanoma. In vitro data and results of a clinical phase I/II trial using DC tumor fusions in p...

Full description

Saved in:

Bibliographic Details
Published in:	Human gene therapy Vol. 14; no. 5; p. 483
Main Authors:	Märten, Angela, Renoth, Sabine, Heinicke, Thomas, Albers, Peter, Pauli, Andreas, Mey, Ulrich, Caspari, Reiner, Flieger, Dimitri, Hanfland, Peter, Von Ruecker, Alexander, Eis-Hübinger, Anna M, Müller, Stefan, Schwaner, Ingo, Lohmann, Uwe, Heylmann, Guido, Sauerbruch, Tilman, Schmidt-Wolf, Ingo G H
Format:	Journal Article
Language:	English
Published:	United States 20-03-2003
Subjects:	Adult Aged Antigens, CD - metabolism Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - therapy Cell Fusion Cytokines - biosynthesis Cytokines - blood Cytotoxicity Tests, Immunologic Dendritic Cells - cytology Dendritic Cells - immunology Fluorescent Antibody Technique Humans Isoantigens - immunology Kidney Neoplasms - immunology Kidney Neoplasms - pathology Kidney Neoplasms - therapy Lymphocyte Activation Male Microscopy, Fluorescence Middle Aged Neoplasm Metastasis T-Lymphocytes, Cytotoxic - immunology Treatment Outcome Tumor Cells, Cultured
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!