Mass spectrometry at low and high mass

The introduction of novel methods as well as expanding applications to diverse areas highlight truly impressive progress in mass spectrometry. These developments are illustrated here by two seemingly different areas of research: new methods designed for the determination of isotopic enrichment and n...

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Bibliographic Details
Published in:	Current opinion in chemical biology Vol. 1; no. 3; pp. 399 - 409
Main Author:	Pyrek, Jan St
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-1997
Subjects:	Biopolymers - chemistry Isotope Labeling Mass Spectrometry - instrumentation Mass Spectrometry - methods Molecular Weight ESI electrospray ionization GC-MS gas chromatography-mass spectrometry HGH human growth hormone SIM selected-ion monitoring LC-MS liquid chromatography-mass spectrometry MW molecular weight PD 252Cf plasma desorption/ionization MALDI matrix-assisted laser desorption/ionization m/z mass-to-charge ratio CRIMS chemical reaction interface mass spectrometry TOF-MS time-of-flight mass spectrometry MS mass spectrometry IRM isotope-ratio monitoring FT-ICR-MS Fourier transform-ion cyclotron resonance-mass spectrometry MII monoisotopic ion
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Summary:	The introduction of novel methods as well as expanding applications to diverse areas highlight truly impressive progress in mass spectrometry. These developments are illustrated here by two seemingly different areas of research: new methods designed for the determination of isotopic enrichment and novel ionization methods; and mass analyzers which have enabled the precise determination of the molecular weight of proteins and large oligonucleotides.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1367-5931 1879-0402
DOI:	10.1016/S1367-5931(97)80080-4