Trends in antifungal susceptibility of Candida species--one year observation

• Published in: Polish journal of microbiology Vol. 63; no. 2; pp. 217 - 222
• Main Authors: Gołaś, M, Netsvyetayeva, I, Sikora, M, Piskorska, K, Sulik-Tyszka, B, Swoboda-Kopeć, E
• Format: Journal Article
• Language: English
• Published: Poland De Gruyter Poland 2014
• Subjects: Antifungal Agents - pharmacology; Candida - classification; Candida - drug effects; Candidiasis, Invasive - microbiology; Drug Resistance, Fungal; Fungicides; Humans; Microbial Sensitivity Tests
• ISSN: 1733-1331; 2544-4646
• DOI: 10.33073/pjm-2014-028

In the past years opportunistic fungal infections have seriously increased, mainly in immunocompromised patients. The aim of the study was to determine the prevalence of yeast-like fungi in invasive candidiasis and to estimate its susceptibility to chosen antifungal agents. One hundred and sixty strains of yeast-like fungi were cultured from various clinical material: samples from lower respiratory tract, blood, the peritoneal cavity and others. The susceptibility tests were established according to the quantitative E-test method. The Candida genus represented the main etiological factor of invasive candidiasis. The predominant species were: C. glabrata (71/160), C. albicans (34/160), C. krusei (17/160), C. tropicalis (14/160). All tested strains were the most resistant to itraconazole. Candida glabrata presented the 100% susceptibility to amphotericin B and caspofungin and was the least susceptible to itraconazole, posaconazole and voriconazole. Candida albicans was the most susceptible species to all antymicotics.