Epidemiological-molecular profile of variants associated with type 2 diabetes mellitus in indigenous populations from the Brazilian Amazon

Aims: While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM genetics focuses on European and Asian populations, leaving underrepresented groups, such as indigenous populations with high diabetes pr...

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Published in:	Diabetes research and clinical practice Vol. 199; p. 110641
Main Authors:	Monte, Natasha, Carla Gomes Rodrigues, Juliana, Wallacy Morikawa Souza Vinagre, Lui, Favacho Pastana, Lucas, Leite de Alcântara, Angélica, Pereira Colares Leitão, Luciana, Maurício Ribeiro-dos-Santos, André, Rodrigues Fernandes, Marianne, Ribeiro-dos-Santos, Ândrea, Farias Guerreiro, João, Pimentel Assumpção, Paulo, Santos, Sidney, José de Souza, Sandro, Pereira Carneiro dos Santos, Ney
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-05-2023
Subjects:	Brazil - epidemiology Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Ethnicity Exome Genetic Predisposition to Disease Genomics Humans Indigenous Peoples - genetics Indigenous populations T2DM Brazil Exome Indigenous populations T2DM Genomics
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Abstract	Aims: While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM genetics focuses on European and Asian populations, leaving underrepresented groups, such as indigenous populations with high diabetes prevalence, understudied. Methods: We characterized the molecular profile of 10 genes involved in T2DM risk through complete exome sequencing of 64 indigenous individuals belonging to 12 different Amazonian ethnic groups. Results: The analysis revealed 157 variants, including four exclusive variants in the indigenous population located in the NOTCH2 and WFS1 genes with a modifier or moderate impact on protein effectiveness. Furthermore, a high impact variant in NOTCH2 was also found. Additionally, the frequency of 10 variants in the indigenous group showed significant differences when compared to other global populations that were evaluated. Conclusion: Our study identified 4 novel variants associated with T2DM in the NOTCH2 and WFS1 genes in the Amazonian indigenous populations we studied. In addition, a variant with a high predicted impact in NOTCH2 was also observed. These findings represent a valuable starting point for conducting further association and functional studies, which could help to improve our understanding of the unique characteristics of this population.
AbstractList	AIMSWhile lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM genetics focuses on European and Asian populations, leaving underrepresented groups, such as indigenous populations with high diabetes prevalence, understudied. METHODSWe characterized the molecular profile of 10 genes involved in T2DM risk through complete exome sequencing of 64 indigenous individuals belonging to 12 different Amazonian ethnic groups. RESULTSThe analysis revealed 157 variants, including four exclusive variants in the indigenous population located in the NOTCH2 and WFS1 genes with a modifier or moderate impact on protein effectiveness. Furthermore, a high impact variant in NOTCH2 was also found. Additionally, the frequency of 10 variants in the indigenous group showed significant differences when compared to other global populations that were evaluated. CONCLUSIONOur study identified 4 novel variants associated with T2DM in the NOTCH2 and WFS1 genes in the Amazonian indigenous populations we studied. In addition, a variant with a high predicted impact in NOTCH2 was also observed. These findings represent a valuable starting point for conducting further association and functional studies, which could help to improve our understanding of the unique characteristics of this population. Aims: While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM genetics focuses on European and Asian populations, leaving underrepresented groups, such as indigenous populations with high diabetes prevalence, understudied. Methods: We characterized the molecular profile of 10 genes involved in T2DM risk through complete exome sequencing of 64 indigenous individuals belonging to 12 different Amazonian ethnic groups. Results: The analysis revealed 157 variants, including four exclusive variants in the indigenous population located in the NOTCH2 and WFS1 genes with a modifier or moderate impact on protein effectiveness. Furthermore, a high impact variant in NOTCH2 was also found. Additionally, the frequency of 10 variants in the indigenous group showed significant differences when compared to other global populations that were evaluated. Conclusion: Our study identified 4 novel variants associated with T2DM in the NOTCH2 and WFS1 genes in the Amazonian indigenous populations we studied. In addition, a variant with a high predicted impact in NOTCH2 was also observed. These findings represent a valuable starting point for conducting further association and functional studies, which could help to improve our understanding of the unique characteristics of this population. While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM genetics focuses on European and Asian populations, leaving underrepresented groups, such as indigenous populations with high diabetes prevalence, understudied. We characterized the molecular profile of 10 genes involved in T2DM risk through complete exome sequencing of 64 indigenous individuals belonging to 12 different Amazonian ethnic groups. The analysis revealed 157 variants, including four exclusive variants in the indigenous population located in the NOTCH2 and WFS1 genes with a modifier or moderate impact on protein effectiveness. Furthermore, a high impact variant in NOTCH2 was also found. Additionally, the frequency of 10 variants in the indigenous group showed significant differences when compared to other global populations that were evaluated. Our study identified 4 novel variants associated with T2DM in the NOTCH2 and WFS1 genes in the Amazonian indigenous populations we studied. In addition, a variant with a high predicted impact in NOTCH2 was also observed. These findings represent a valuable starting point for conducting further association and functional studies, which could help to improve our understanding of the unique characteristics of this population.
ArticleNumber	110641
Author	Monte, Natasha Carla Gomes Rodrigues, Juliana Rodrigues Fernandes, Marianne Farias Guerreiro, João Leite de Alcântara, Angélica José de Souza, Sandro Pimentel Assumpção, Paulo Pereira Carneiro dos Santos, Ney Maurício Ribeiro-dos-Santos, André Santos, Sidney Ribeiro-dos-Santos, Ândrea Favacho Pastana, Lucas Pereira Colares Leitão, Luciana Wallacy Morikawa Souza Vinagre, Lui
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Cites_doi	10.1007/s11892-017-0958-0 10.1111/pedi.12787 10.3390/genes12020142 10.1900/RDS.2010.7.285 10.1080/14767058.2017.1297793 10.1371/journal.pone.0231651 10.1007/s00438-017-1340-2 10.1007/s00125-013-2988-8 10.1016/j.gde.2018.02.003 10.3390/genes13030491 10.2337/db12-1627 10.2337/db09-0920 10.2188/jea.JE20160151 10.1186/s13098-015-0091-7 10.3389/fgene.2020.548507 10.2337/dc16-0153 10.1038/srep43709 10.1002/ajhb.22714 10.1177/0306312712454044 10.1186/s12884-016-0823-1 10.1038/nature15393 10.1016/j.isci.2021.102893
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References	Tarnowski, Malinowski, Safranow, Dziedziejko, Pawlik (b0110) 2018; 31 Genecards. <https://www.genecards.org/>. [acessed 10 May 2022]. Ribeiro-Dos-Santos, Vidal, Vinasco-Sandoval, Guerreiro, Santos, Ribeiro-Dos-Santos (b0055) 2020; 11 Simons N, Dekker JM, van Greevenbroek MM, Nijpels G, 't Hart LM, van der Kallen CJ, et al. A common gene variant in glucokinase regulatory protein interacts with glucose metabolism on diabetic dyslipidemia: the combined CODAM and Hoorn studies. Diabetes care 2016;39(10):1811–7. doi:10.2337/dc16-0153. Alharbi, Ali Khan, Syed, Alharbi, Mohammed, Vinodson (b0115) 2015; 7 variants associated with human metabolic regulation and diseases. iScience 2021;24(8):102893. doi: 10.1016/j.isci.2021.102893. 1000 Genomes Project Consortium A global reference for human genetic variation. Nature. 2015;526:68–74. doi: 10.1038/nature15393. Jan, Saeed, Afridi, Khuda, Shabbir, Khan (b0085) 2021 Jonsson, Ladenvall, Ahluwalia, Kravic, Krus, Taneera (b0105) 2013; 62 Sahota (b0020) 2012; 42 Moura, Coelho, Balbino, Crovella, Brandão (b0135) 2015; 27 gene associated with hereditary breast cancer in indigenous populations of the brazilian Amazon. Genes 2021;12(2):142. doi:10.3390/genes12020142. Ramos, Mendes, Tanikawa, Amador, Santos, Santos (b0040) 2016; 16 Chistiakov, Khodyrev, Smetanina, Bel'chikova, Suplotova, Nosikov (b0080) 2010; 7 MedlinePlus. <https://medlineplus.gov/>. [acessed 02 May 2022]. Anghebem-Oliveira, Webber, Alberton, Souza, Klassen, Picheth (b0090) 2016 Wu, Jing, Dong, Kuang, Li, Huang (b0125) 2017; 7 Kodama, Fujihara, Ishiguro, Horikawa, Ohara, Yachi (b0035) 2018; 28 De T, Gonçalves A, Speed D, Froguel P, NFBC consortium, Gaffney DJ, et al. Signatures of Malone, Hansen (b0005) 2018; 20 Yeh, Hsu, Teng, Wu, Chou, Ko (b0100) 2022; 13 Fawcett, Wheeler, Morris, Ricketts, Hallmans, Rolandsson (b0075) 2010; 59 Morris (b0010) 2018; 50 Franceschini, Haack, Göring, Voruganti, Laston, Almasy (b0130) 2013; 56 Granados-Silvestre, Ortiz-López, Granados, Canizales-Quinteros, Peñaloza-Espinosa, Lechuga (b0025) 2017; 292 Rodrigues, Souza, Pastana, Ribeiro-dos-Santos, Fernandes, Pinto (b0045) 2020; 15 Dobbin EAF, Medeiros JAG, Costa MSCR, Rodrigues JCG, Guerreiro JF, Kroll J E, et al. (2021). Identification of variants (rs11571707, rs144848, and rs11571769) in the Merino, Miriam, Leong, Meigs (b0015) 2017; 17 Franceschini (10.1016/j.diabres.2023.110641_b0130) 2013; 56 Wu (10.1016/j.diabres.2023.110641_b0125) 2017; 7 Merino (10.1016/j.diabres.2023.110641_b0015) 2017; 17 Anghebem-Oliveira (10.1016/j.diabres.2023.110641_b0090) 2016 Morris (10.1016/j.diabres.2023.110641_b0010) 2018; 50 Tarnowski (10.1016/j.diabres.2023.110641_b0110) 2018; 31 10.1016/j.diabres.2023.110641_b0060 Kodama (10.1016/j.diabres.2023.110641_b0035) 2018; 28 Malone (10.1016/j.diabres.2023.110641_b0005) 2018; 20 Granados-Silvestre (10.1016/j.diabres.2023.110641_b0025) 2017; 292 Fawcett (10.1016/j.diabres.2023.110641_b0075) 2010; 59 Alharbi (10.1016/j.diabres.2023.110641_b0115) 2015; 7 Ribeiro-Dos-Santos (10.1016/j.diabres.2023.110641_b0055) 2020; 11 Rodrigues (10.1016/j.diabres.2023.110641_b0045) 2020; 15 Chistiakov (10.1016/j.diabres.2023.110641_b0080) 2010; 7 10.1016/j.diabres.2023.110641_b0065 10.1016/j.diabres.2023.110641_b0120 10.1016/j.diabres.2023.110641_b0030 10.1016/j.diabres.2023.110641_b0095 Ramos (10.1016/j.diabres.2023.110641_b0040) 2016; 16 Yeh (10.1016/j.diabres.2023.110641_b0100) 2022; 13 Moura (10.1016/j.diabres.2023.110641_b0135) 2015; 27 10.1016/j.diabres.2023.110641_b0070 Jan (10.1016/j.diabres.2023.110641_b0085) 2021 Sahota (10.1016/j.diabres.2023.110641_b0020) 2012; 42 Jonsson (10.1016/j.diabres.2023.110641_b0105) 2013; 62
References_xml	– volume: 42 start-page: 821 year: 2012 end-page: 842 ident: b0020 article-title: Genetic histories: Native American’s accounts of being at risk for diabetes publication-title: Soc Stud Sci contributor: fullname: Sahota – volume: 62 start-page: 2978 year: 2013 end-page: 2983 ident: b0105 article-title: Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans publication-title: Diabetes contributor: fullname: Taneera – volume: 59 start-page: 741 year: 2010 end-page: 746 ident: b0075 article-title: Detailed investigation of the role of common and low-frequency publication-title: Diabetes contributor: fullname: Rolandsson – start-page: 6669731 year: 2021 ident: b0085 article-title: Association of publication-title: Journal of diabetes research contributor: fullname: Khan – volume: 13 start-page: 491 year: 2022 ident: b0100 article-title: Pleiotropic Effects of Common and Rare publication-title: Genes contributor: fullname: Ko – volume: 7 start-page: 285 year: 2010 end-page: 292 ident: b0080 article-title: A publication-title: The review of diabetic studies: RDS contributor: fullname: Nosikov – volume: 27 start-page: 674 year: 2015 end-page: 680 ident: b0135 article-title: Meta-analysis of brazilian genetic admixture and comparison with other Latin America countries publication-title: Am J Hum Biol contributor: fullname: Brandão – volume: 31 start-page: 837 year: 2018 end-page: 842 ident: b0110 article-title: , publication-title: J Matern Fetal Neonatal Med contributor: fullname: Pawlik – volume: 17 start-page: 135 year: 2017 ident: b0015 article-title: A decade of genetic and metabolomic contributions to type 2 diabetes risk prediction publication-title: Curr Diab Rep contributor: fullname: Meigs – volume: 16 start-page: 30 year: 2016 ident: b0040 article-title: Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study publication-title: BMC Pregnancy Childbirth contributor: fullname: Santos – volume: 15 year: 2020 ident: b0045 article-title: Identification of publication-title: PLoS One contributor: fullname: Pinto – year: 2016 ident: b0090 article-title: The publication-title: J Clin Lab Anal contributor: fullname: Picheth – volume: 7 start-page: 92 year: 2015 ident: b0115 article-title: Association of publication-title: Diabetol Metab Syndr contributor: fullname: Vinodson – volume: 56 start-page: 2194 year: 2013 end-page: 2202 ident: b0130 article-title: Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart family study publication-title: Diabetologia contributor: fullname: Almasy – volume: 50 start-page: 41 year: 2018 end-page: 51 ident: b0010 article-title: Progress in defining the genetic contribution to type 2 diabetes susceptibility publication-title: Curr Opin Genet Dev contributor: fullname: Morris – volume: 28 start-page: 3 year: 2018 end-page: 18 ident: b0035 article-title: Quantitative relationship between cumulative risk alleles based on genome-wide association studies and type 2 diabetes mellitus: a systematic review and meta-analysis publication-title: J Epidemiol contributor: fullname: Yachi – volume: 11 year: 2020 ident: b0055 article-title: Exome sequencing of native populations from the Amazon reveals patterns on the peopling of south america publication-title: Front Genet contributor: fullname: Ribeiro-Dos-Santos – volume: 20 start-page: 5 year: 2018 end-page: 9 ident: b0005 article-title: Does obesity cause type 2 diabetes? Or is it the opposite? publication-title: A commentary Pediatric diabetes contributor: fullname: Hansen – volume: 7 start-page: 43709 year: 2017 ident: b0125 article-title: Functional annotation of sixty-five type-2 diabetes risk SNPs and its application in risk prediction publication-title: Sci Rep contributor: fullname: Huang – volume: 292 start-page: 1209 year: 2017 end-page: 1219 ident: b0025 article-title: Susceptibility background for type 2 diabetes in eleven Mexican indigenous populations: publication-title: Mol Genet Genomics contributor: fullname: Lechuga – volume: 17 start-page: 135 issue: 12 year: 2017 ident: 10.1016/j.diabres.2023.110641_b0015 article-title: A decade of genetic and metabolomic contributions to type 2 diabetes risk prediction publication-title: Curr Diab Rep doi: 10.1007/s11892-017-0958-0 contributor: fullname: Merino – volume: 20 start-page: 5 issue: 1 year: 2018 ident: 10.1016/j.diabres.2023.110641_b0005 article-title: Does obesity cause type 2 diabetes? Or is it the opposite? publication-title: A commentary Pediatric diabetes doi: 10.1111/pedi.12787 contributor: fullname: Malone – ident: 10.1016/j.diabres.2023.110641_b0030 doi: 10.3390/genes12020142 – ident: 10.1016/j.diabres.2023.110641_b0065 – volume: 7 start-page: 285 issue: 4 year: 2010 ident: 10.1016/j.diabres.2023.110641_b0080 article-title: A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients publication-title: The review of diabetic studies: RDS doi: 10.1900/RDS.2010.7.285 contributor: fullname: Chistiakov – volume: 31 start-page: 837 issue: 7 year: 2018 ident: 10.1016/j.diabres.2023.110641_b0110 article-title: HNF1B, TSPAN8 and NOTCH2 gene polymorphisms in women with gestational diabetes publication-title: J Matern Fetal Neonatal Med doi: 10.1080/14767058.2017.1297793 contributor: fullname: Tarnowski – volume: 15 issue: 4 year: 2020 ident: 10.1016/j.diabres.2023.110641_b0045 article-title: Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil publication-title: PLoS One doi: 10.1371/journal.pone.0231651 contributor: fullname: Rodrigues – volume: 292 start-page: 1209 issue: 6 year: 2017 ident: 10.1016/j.diabres.2023.110641_b0025 article-title: Susceptibility background for type 2 diabetes in eleven Mexican indigenous populations: HNF4A gene analysis publication-title: Mol Genet Genomics doi: 10.1007/s00438-017-1340-2 contributor: fullname: Granados-Silvestre – year: 2016 ident: 10.1016/j.diabres.2023.110641_b0090 article-title: The GCKR gene polymorphism rs780094 is a risk factor for gestational diabetes in a brazilian population publication-title: J Clin Lab Anal contributor: fullname: Anghebem-Oliveira – volume: 56 start-page: 2194 issue: 10 year: 2013 ident: 10.1016/j.diabres.2023.110641_b0130 article-title: Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart family study publication-title: Diabetologia doi: 10.1007/s00125-013-2988-8 contributor: fullname: Franceschini – start-page: 6669731 year: 2021 ident: 10.1016/j.diabres.2023.110641_b0085 article-title: Association of HLA-B gene polymorphisms with type 2 diabetes in pashtun ethnic population of Khyber Pakhtunkhwa, Pakistan publication-title: Journal of diabetes research contributor: fullname: Jan – volume: 50 start-page: 41 year: 2018 ident: 10.1016/j.diabres.2023.110641_b0010 article-title: Progress in defining the genetic contribution to type 2 diabetes susceptibility publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2018.02.003 contributor: fullname: Morris – ident: 10.1016/j.diabres.2023.110641_b0070 – volume: 13 start-page: 491 issue: 3 year: 2022 ident: 10.1016/j.diabres.2023.110641_b0100 article-title: Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits publication-title: Genes doi: 10.3390/genes13030491 contributor: fullname: Yeh – volume: 62 start-page: 2978 issue: 8 year: 2013 ident: 10.1016/j.diabres.2023.110641_b0105 article-title: Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans publication-title: Diabetes doi: 10.2337/db12-1627 contributor: fullname: Jonsson – volume: 59 start-page: 741 issue: 3 year: 2010 ident: 10.1016/j.diabres.2023.110641_b0075 article-title: Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk publication-title: Diabetes doi: 10.2337/db09-0920 contributor: fullname: Fawcett – volume: 28 start-page: 3 issue: 1 year: 2018 ident: 10.1016/j.diabres.2023.110641_b0035 article-title: Quantitative relationship between cumulative risk alleles based on genome-wide association studies and type 2 diabetes mellitus: a systematic review and meta-analysis publication-title: J Epidemiol doi: 10.2188/jea.JE20160151 contributor: fullname: Kodama – volume: 7 start-page: 92 year: 2015 ident: 10.1016/j.diabres.2023.110641_b0115 article-title: Association of JAZF1 and TSPAN8/LGR5 variants in relation to type 2 diabetes mellitus in a Saudi population publication-title: Diabetol Metab Syndr doi: 10.1186/s13098-015-0091-7 contributor: fullname: Alharbi – volume: 11 year: 2020 ident: 10.1016/j.diabres.2023.110641_b0055 article-title: Exome sequencing of native populations from the Amazon reveals patterns on the peopling of south america publication-title: Front Genet doi: 10.3389/fgene.2020.548507 contributor: fullname: Ribeiro-Dos-Santos – ident: 10.1016/j.diabres.2023.110641_b0095 doi: 10.2337/dc16-0153 – volume: 7 start-page: 43709 year: 2017 ident: 10.1016/j.diabres.2023.110641_b0125 article-title: Functional annotation of sixty-five type-2 diabetes risk SNPs and its application in risk prediction publication-title: Sci Rep doi: 10.1038/srep43709 contributor: fullname: Wu – volume: 27 start-page: 674 issue: 5 year: 2015 ident: 10.1016/j.diabres.2023.110641_b0135 article-title: Meta-analysis of brazilian genetic admixture and comparison with other Latin America countries publication-title: Am J Hum Biol doi: 10.1002/ajhb.22714 contributor: fullname: Moura – volume: 42 start-page: 821 issue: 6 year: 2012 ident: 10.1016/j.diabres.2023.110641_b0020 article-title: Genetic histories: Native American’s accounts of being at risk for diabetes publication-title: Soc Stud Sci doi: 10.1177/0306312712454044 contributor: fullname: Sahota – volume: 16 start-page: 30 issue: 1 year: 2016 ident: 10.1016/j.diabres.2023.110641_b0040 article-title: Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study publication-title: BMC Pregnancy Childbirth doi: 10.1186/s12884-016-0823-1 contributor: fullname: Ramos – ident: 10.1016/j.diabres.2023.110641_b0060 doi: 10.1038/nature15393 – ident: 10.1016/j.diabres.2023.110641_b0120 doi: 10.1016/j.isci.2021.102893
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Snippet	Aims: While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on... While lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on T2DM... AIMSWhile lifestyle factors are strongly associated with Type 2 diabetes (T2DM), genetic characteristics also play a role. However, much of the research on...
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SubjectTerms	Brazil - epidemiology Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Ethnicity Exome Genetic Predisposition to Disease Genomics Humans Indigenous Peoples - genetics Indigenous populations T2DM
Title	Epidemiological-molecular profile of variants associated with type 2 diabetes mellitus in indigenous populations from the Brazilian Amazon
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