Using Chitosan or Chitosan Derivatives in Cancer Therapy

Using Chitosan or Chitosan Derivatives in Cancer Therapy

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the li...

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Published in:Polysaccharides Vol. 2; no. 4; pp. 795 - 816
Main Authors: Shakil, Md Salman, Mahmud, Kazi Mustafa, Sayem, Mohammad, Niloy, Mahruba Sultana, Halder, Sajal Kumar, Hossen, Md. Sakib, Uddin, Md. Forhad, Hasan, Md. Ashraful
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-12-2021
Subjects:
anticancer activities
Antimicrobial agents
Antitumor agents
Apoptosis
Bioavailability
Biocompatibility
Biopolymers
Breast cancer
Cancer
Cancer therapies
Cell cycle
Cellulose
Chitin
Chitosan
chitosan derivatives
Cytotoxicity
Drug delivery
Drug delivery systems
Drug dosages
Drug resistance
gene and drug delivery
Gene expression
Growth factors
immunotherapy
Kinases
Ligands
Molecular weight
Nanocomposites
Nanoparticles
Pharmaceutical industry
Polyethylene glycol
Tumor necrosis factor-TNF
Vitamin B
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Abstract Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.
AbstractList Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.
Author Halder, Sajal Kumar
Hossen, Md. Sakib
Uddin, Md. Forhad
Shakil, Md Salman
Hasan, Md. Ashraful
Mahmud, Kazi Mustafa
Sayem, Mohammad
Niloy, Mahruba Sultana
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  surname: Hasan
  fullname: Hasan, Md. Ashraful
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Snippet Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic...
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SubjectTerms anticancer activities
Antimicrobial agents
Antitumor agents
Apoptosis
Bioavailability
Biocompatibility
Biopolymers
Breast cancer
Cancer
Cancer therapies
Cell cycle
Cellulose
Chitin
Chitosan
chitosan derivatives
Cytotoxicity
Drug delivery
Drug delivery systems
Drug dosages
Drug resistance
gene and drug delivery
Gene expression
Growth factors
immunotherapy
Kinases
Ligands
Molecular weight
Nanocomposites
Nanoparticles
Pharmaceutical industry
Polyethylene glycol
Tumor necrosis factor-TNF
Vitamin B
Title Using Chitosan or Chitosan Derivatives in Cancer Therapy
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https://doaj.org/article/c765992d0824492cbc73fc335d9bcb21
Volume 2
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