Polyplex-embedding in polyelectrolyte multilayers for gene delivery

Polyplex-embedding in polyelectrolyte multilayers for gene delivery

In this work, incorporation of plasmid DNA, pre-complexed with PEI, into polyelectrolyte multilayers has been studied to further develop platforms for local gene delivery. Polyplex embedding in synthetic and naturally degradable architectures was efficient for transfection of human hepato-cellular c...

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Bibliographic Details
Published in:Biochimica et biophysica acta Vol. 1758; no. 3; pp. 419 - 422
Main Authors: Meyer, Florent, Ball, Vincent, Schaaf, Pierre, Voegel, Jean Claude, Ogier, Joelle
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-03-2006
Subjects:
Carcinoma, Hepatocellular
Cell Line, Tumor
DNA - chemistry
Electrolytes - chemistry
Gene delivery
Humans
Liver Neoplasms
Plasmids - chemistry
Polyelectrolyte multilayer
Polyethyleneimine - chemistry
Polyplex
Transfection - methods
Polyelectrolyte multilayer
Gene delivery
Polyplex
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Summary:In this work, incorporation of plasmid DNA, pre-complexed with PEI, into polyelectrolyte multilayers has been studied to further develop platforms for local gene delivery. Polyplex embedding in synthetic and naturally degradable architectures was efficient for transfection of human hepato-cellular carcinoma cells.
ISSN:0005-2736
0006-3002
1879-2642
DOI:10.1016/j.bbamem.2005.11.015