Sex and sex hormones in cardiac stress—Mechanistic insights

•Important sex differences are evident in cardiac stress responses.•Cardiac androgen/estrogen receptor activation modulates basal contractile function.•Sex steroids exhibit complex & context dependent actions in cardiac stress.•Both estrogens and androgens can have beneficial and detrimental eff...

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Bibliographic Details
Published in:	The Journal of steroid biochemistry and molecular biology Vol. 137; pp. 124 - 135
Main Authors:	Bell, James R., Bernasochi, Gabriel B., Varma, Upasna, Raaijmakers, Antonia J.A., Delbridge, Lea M.D.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2013
Subjects:	Aromatase Ca handling Cardiac hypertrophy Contractile function Estrogen Female Gonadal Steroid Hormones - physiology Heart Heart - physiopathology Humans Ischemia Male Receptors, Androgen - metabolism Receptors, Estrogen - metabolism Stress, Physiological Testosterone Heart Testosterone Ischemia Aromatase Contractile function Estrogen Cardiac hypertrophy Ca handling
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