Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training

• Published in: Experimental gerontology Vol. 111; pp. 180 - 187
• Main Authors: de Lemos Muller, Carlos Henrique, Rech, Anderson, Botton, Cíntia Ehlers, Schroeder, Helena Trevisan, Bock, Patricia Martins, Farinha, Juliano Boufleur, Lopez, Pedro, Schöler, Cinthia Maria, Grigolo, Gisele Bettú, Coelho, Jerônimo, Kowalewski, Lucas Stahlhöfer, Rodrigues, Maria Inês Lavina, de Azevedo, Marcela Alves, Quincozes-Santos, André, Rodrigues-Krause, Josianne, Reischak-Oliveira, Alvaro, Pinto, Ronei Silveira, De Vito, Giuseppe, de Bittencourt Júnior, Paulo Ivo Homem, Krause, Mauricio
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01-10-2018
• Subjects: Aging; Blood mononuclear cells; Heat shock response; Resistance training; Type 2 diabetes; Type 2 diabetes; Heat shock response; Aging; Blood mononuclear cells; Resistance training
• ISSN: 0531-5565; 1873-6815
• DOI: 10.1016/j.exger.2018.07.014

Recent evidence suggests that the anti-inflammatory heat shock response (HSR) is reduced in aging and diabetes. In this study we compared HSR between healthy middle-aged adults, healthy elderly and type 2 diabetic (T2DM) elderly, and tested whether resistance training (RT) could improve the HSR in T2DM group. Thirty sedentary participants volunteered for this study. HSR (assessed as the capacity to export HSP72 during heat stress) was measured in the blood and compared between the groups. HSR was similar between healthy middle-aged and healthy elderly volunteers, but diminished in elderly T2DM (p < 0.001). Hence, T2DM subjects (n = 12) were submitted to a 12-week RT program, because exercise is a physiological HSR inducer. HSR, cytokines, metabolic parameters and visceral adipose tissue (VAT) were measured before and after the RT. Remarkably, VAT was negatively correlated with HSR (r = − 0.49, p < 0.01) while RT improved the HSR and reduced inflammation [TNF-α: from 51.5 ± 9 to 40.7 ± 4 pg/mL and TNF-α/IL-10 ratio: from 1.55 ± 0.3 to 1.16 ± 0.2 (p < 0.001)], without affecting other parameters. All together, these findings confirm the hypothesis that the anti-inflammatory HSR is depressed in elderly diabetic people, but can be partially restored by RT.
•Heat Shock Response (HSR) is similar in healthy middle-aged and elderly people, but is blunted in aged T2DM individuals.•Visceral Adipose Tissue (VAT) is increased with age, and the increased VAT is correlated with a lower HSR.•Resistance training (RT) is an efficient intervention to restore the HSR and reduce inflammation in aged T2DM individuals.•Restoration of HSR may delay the appearance and the establishment of inflammatory-related diseases.