Mechanochemical Rules for Shape-Shifting Filaments that Remodel Membranes

Mechanochemical Rules for Shape-Shifting Filaments that Remodel Membranes

The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of...

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Bibliographic Details
Published in:Physical review letters Vol. 129; no. 26; p. 268101
Main Authors: Meadowcroft, Billie, Palaia, Ivan, Pfitzner, Anna-Katharina, Roux, Aurélien, Baum, Buzz, Šarić, Anđela
Format: Journal Article
Language:English
Published: United States 23-12-2022
Subjects:
Cytoskeleton
Membranes
Polymers - chemistry
Online Access:Get full text
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Description
Summary:The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein-membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodeling and show this mechanism of sequential polymer assembly lowers the energetic barrier for membrane deformation.
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content type line 23
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.129.268101