Human IgG subclass cross-species reactivity to mouse and cynomolgus monkey Fcγ receptors

•Affinities of human, murine and cyno monkey FcγRs against human IgGs is presented.•Cyno FcγRs had higher affinities to human IgGs compared to corresponding human FcγRs.•Cyno FcγRI had nanomolar affinity to human IgG4 PAA while human FcγRI bound weakly. In therapeutic antibody discovery and early de...

Full description

Bibliographic Details

Published in:	Immunology letters Vol. 197; pp. 1 - 8
Main Authors:	Derebe, Mehabaw G., Nanjunda, Rupesh K., Gilliland, Gary L., Lacy, Eilyn R., Chiu, Mark L.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-05-2018
Subjects:	Animal models Cross-species reactivity Fc-silent IgGs Fcγ receptors Immunoglobulin G (IgG) Surface Plasmon Resonance (SPR) Immunoglobulin G (IgG) Animal models Surface Plasmon Resonance (SPR) Fcγ receptors Fc-silent IgGs Cross-species reactivity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!