Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination

Autism spectrum disorder (ASD) is a neurodevelopmental disorder of heterogenous etiology exhibiting a challenge in understanding its exact neuro-pathophysiology. Recently, peroxisome proliferator activated receptor (PPAR)-α activation was found to play a fundamental role in neuroprotection and impro...

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Bibliographic Details
Published in:	Progress in neuro-psychopharmacology & biological psychiatry Vol. 116; p. 110522
Main Authors:	Elnahas, Esraa M., Abuelezz, Sally A., Mohamad, Magda I., Nabil, Mai M., Abdelraouf, Sahar M., Bahaa, Nevine, Hassan, Ghada A.M., Aboul-Fotouh, Sawsan
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 08-06-2022
Subjects:	Animals Apoptosis ASD Astrocytes and Tauopathy Autism Spectrum Disorder - chemically induced Autism Spectrum Disorder - drug therapy Autism Spectrum Disorder - metabolism Autistic Disorder - chemically induced Behavior, Animal Disease Models, Animal Female Male Metformin - adverse effects Metformin and risperidone Peroxisome Proliferator-Activated Receptors - adverse effects PPAR-α Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar Risperidone - pharmacology Risperidone - therapeutic use Tauopathies Valproic Acid - pharmacology ASD Metformin and risperidone Astrocytes and Tauopathy PPAR-α Apoptosis
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