Intrapleural Hyaluronidase in Viscous Malignant Mesothelioma Pleural Effusion

Malignant pleural effusion is common in mesothelioma. We report a case of viscous recurrent malignant mesothelioma pleural effusion. The viscosity was due to the presence of hyaluronic acid and resulted in prolonged drainage time. The use of intrapleural hyaluronidase significantly reduced fluid vis...

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Bibliographic Details
Published in:	Chest Vol. 160; no. 6; pp. e609 - e611
Main Authors:	Foo, Chuan T., Paterson, Anna, Duckworth, Adam, Herre, Jurgen
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2021
Subjects:	Aged Combined Modality Therapy Drainage Exudates and Transudates - drug effects Humans hyaluronic acid hyaluronidase Hyaluronoglucosaminidase - therapeutic use Male malignant pleural effusion mesothelioma Mesothelioma, Malignant - therapy Pleural Effusion, Malignant - therapy Pleural Neoplasms - therapy viscous pleural effusion hyaluronidase malignant pleural effusion MPE viscous pleural effusion mesothelioma hyaluronic acid
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Summary:	Malignant pleural effusion is common in mesothelioma. We report a case of viscous recurrent malignant mesothelioma pleural effusion. The viscosity was due to the presence of hyaluronic acid and resulted in prolonged drainage time. The use of intrapleural hyaluronidase significantly reduced fluid viscosity and drainage duration. No adverse reactions were noted. This novel case highlights the feasibility and safety of the use of intrapleural hyaluronidase in the management of hyaluronic acid-rich viscous malignant pleural effusion.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0012-3692 1931-3543
DOI:	10.1016/j.chest.2021.07.031