The influence of Li+ ions on pepsin and trypsin activity in vitro

• Published in: Journal of trace elements in medicine and biology Vol. 66; p. 126763
• Main Authors: Kabzińska, Karolina, Cisek-Woźniak, Angelika, Czajeczny, Dominik, Mruczyk, Kinga, Wójciak, Rafał W.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01-07-2021
• Subjects: Enzymes; Lithium carbonate; Lithium citrate; Pepsin; Trypsin; Enzymes; Trypsin; Pepsin; Lithium carbonate; Lithium citrate
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2021.126763

The paper presents a study on the influence of different lithium carbonate and lithium citrate concentration on proteolytic enzymes, namely pepsin and trypsin, in vitro. Lithium can directly affect enzyme activity. Its influence on many bodily functions in both ill and healthy people has been proven.
To assess the influence of Li+ ions concentration and the substrate/enzyme ratio on pepsin and trypsin activity in vitro, 60 factorial experiments were conducted (each repeated 30 times).
For both enzymes, statistically significant changes in their activity under the influence of lihium carbonate and lithium citrate were observed. The biggest increase in enzyme activity reached even 198.6 % and the largest decrease in enzyme activity reached about 50 %.
The study shows that both organic and inorganic forms of lithium salts cause changes in the activity of digestive enzymes. Different concentrations of lithium carbonate and lithium citrate stimulate or inhibit the activity of trypsin and pepsin.