Bidirectional alloreactivity A proposed microchimerism-based solution to the NIMA paradox

The NIMA paradox is the observation that in transplants of allogeneic kidneys or hematopoietic stem cells, siblings benefit from re-exposure to non-inherited maternal antigens (NIMA), whereas re-exposure to a transplant from mother herself, theoretically the ideal "NIMA" donor, does not yi...

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Bibliographic Details
Published in:	Chimerism Vol. 3; no. 2; pp. 29 - 36
Main Authors:	Burlingham, William J., Benichou, Gilles
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01-04-2012 Landes Bioscience
Subjects:	alloreactivity Animals bidirectional Binding Biology Bioscience Calcium Cancer Cell Chimerism Cord Blood Stem Cell Transplantation Cycle Graft vs Host Disease - immunology Humans Immune Tolerance - immunology Isoantigens - immunology Kidney Transplantation Landes microchimerism Organogenesis Proteins regulation Review tolerance Transplantation Tolerance - immunology Transplantation, Homologous
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Summary:	The NIMA paradox is the observation that in transplants of allogeneic kidneys or hematopoietic stem cells, siblings benefit from re-exposure to non-inherited maternal antigens (NIMA), whereas re-exposure to a transplant from mother herself, theoretically the ideal "NIMA" donor, does not yield clinical results superior to a father-donated allograft. Recent observations of bidirectional alloreactivity in kidney and cord blood transplantation offer a possible solution to this paradox. If correct, the proposed solution points the way to clinical applications of microchimerism in solid organ and hematopoetic transplants.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1938-1956 1938-1964
DOI:	10.4161/chim.21668