Association of serum vitamin D levels with chronic disease and mortality
Introduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. Objectives: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and...
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| Published in: | Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 37; no. 2; pp. 335 - 342 |
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| Abstract | Introduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. Objectives: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. Methods: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D supplementation, and who were selected using a cluster random sampling design (n = 1,705). The analysis was focused on metabolic disorders (type-2 diabetes mellitus [T2DM] and obesity), autoimmune disorders, and mortality. Multivariate logistic regression analyses were performed. Results: low 25-(OH)-D3 levels were reported in 1,433 (84.0%) patients, of which 774 (45.4%) had insufficiency (20-29 ng/mL) and 659 (38.6%) patients had deficiency (< 20 ng/mL). Lower 25-(OH)-D3 levels in T2DM patients were associated with higher glycosylated hemoglobin levels (p < 0.001). Patients with 25-(OH)-D3 levels < 12.5 ng/mL had a higher mortality risk than those with levels ≥ 12.5 ng/mL (HR: 3.339; 95% CI: 1.342-8.308). We observed lower 25-(OH)-D3 levels in patients with grade-III obesity (p = 0.01). We found a higher risk of 25-(OH)-D3 deficiency in rheumatoid arthritis, type-1 diabetes, and systemic lupus erythematosus (p = 0.032, p = 0.002, p = 0.049, respectively). Conclusions: we found a significant relationship between 25-(OH)-D3 levels and glycemic control, body mass index, autoimmune disease, and mortality risk. Nevertheless, whether hypovitaminosis D plays a causal role or is a consequence of chronic disease remains controversial. |
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| AbstractList | INTRODUCTIONIntroduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. Objectives: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. Methods: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D supplementation, and who were selected using a cluster random sampling design (n = 1,705). The analysis was focused on metabolic disorders (type-2 diabetes mellitus [T2DM] and obesity), autoimmune disorders, and mortality. Multivariate logistic regression analyses were performed. Results: low 25-(OH)-D3 levels were reported in 1,433 (84.0%) patients, of which 774 (45.4%) had insufficiency (20-29 ng/mL) and 659 (38.6%) patients had deficiency (< 20 ng/mL). Lower 25-(OH)-D3 levels in T2DM patients were associated with higher glycosylated hemoglobin levels (p < 0.001). Patients with 25-(OH)-D3 levels < 12.5 ng/mL had a higher mortality risk than those with levels ≥ 12.5 ng/mL (HR: 3.339; 95% CI: 1.342-8.308). We observed lower 25-(OH)-D3 levels in patients with grade-III obesity (p = 0.01). We found a higher risk of 25-(OH)-D3 deficiency in rheumatoid arthritis, type-1 diabetes, and systemic lupus erythematosus (p = 0.032, p = 0.002, p = 0.049, respectively). Conclusions: we found a significant relationship between 25-(OH)-D3 levels and glycemic control, body mass index, autoimmune disease, and mortality risk. Nevertheless, whether hypovitaminosis D plays a causal role or is a consequence of chronic disease remains controversial. Introduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. Objectives: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. Methods: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D supplementation, and who were selected using a cluster random sampling design (n = 1,705). The analysis was focused on metabolic disorders (type-2 diabetes mellitus [T2DM] and obesity), autoimmune disorders, and mortality. Multivariate logistic regression analyses were performed. Results: low 25-(OH)-D3 levels were reported in 1,433 (84.0%) patients, of which 774 (45.4%) had insufficiency (20-29 ng/mL) and 659 (38.6%) patients had deficiency (< 20 ng/mL). Lower 25-(OH)-D3 levels in T2DM patients were associated with higher glycosylated hemoglobin levels (p < 0.001). Patients with 25-(OH)-D3 levels < 12.5 ng/mL had a higher mortality risk than those with levels ≥ 12.5 ng/mL (HR: 3.339; 95% CI: 1.342-8.308). We observed lower 25-(OH)-D3 levels in patients with grade-III obesity (p = 0.01). We found a higher risk of 25-(OH)-D3 deficiency in rheumatoid arthritis, type-1 diabetes, and systemic lupus erythematosus (p = 0.032, p = 0.002, p = 0.049, respectively). Conclusions: we found a significant relationship between 25-(OH)-D3 levels and glycemic control, body mass index, autoimmune disease, and mortality risk. Nevertheless, whether hypovitaminosis D plays a causal role or is a consequence of chronic disease remains controversial. Abstract Introduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. Objectives: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. Methods: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D supplementation, and who were selected using a cluster random sampling design (n = 1,705). The analysis was focused on metabolic disorders (type-2 diabetes mellitus [T2DM] and obesity), autoimmune disorders, and mortality. Multivariate logistic regression analyses were performed. Results: low 25-(OH)-D3 levels were reported in 1,433 (84.0 %) patients, of which 774 (45.4 %) had insufficiency (20-29 ng/mL) and 659 (38.6 %) patients had deficiency (< 20 ng/mL). Lower 25-(OH)-D3 levels in T2DM patients were associated with higher glycosylated hemoglobin levels (p < 0.001). Patients with 25-(OH)-D3 levels < 12.5 ng/mL had a higher mortality risk than those with levels ≥ 12.5 ng/mL (HR: 3.339; 95 % CI: 1.342-8.308). We observed lower 25-(OH)-D3 levels in patients with grade-III obesity (p = 0.01). We found a higher risk of 25-(OH)-D3 deficiency in rheumatoid arthritis, type-1 diabetes, and systemic lupus erythematosus (p = 0.032, p = 0.002, p = 0.049, respectively). Conclusions: we found a significant relationship between 25-(OH)-D3 levels and glycemic control, body mass index, autoimmune disease, and mortality risk. Nevertheless, whether hypovitaminosis D plays a causal role or is a consequence of chronic disease remains controversial. |
| Author | Laguna Bárcenas, Sara Del Carmen Corral Orozco, Mariel Morales Montalvo, Susana Isabel López Navarro, Juan Manuel Sánchez Landa, Elizabet Abella Roa, María Fernanda Múzquiz Aguirre, Sebastián Osorio Landa, Hillary Kimberly Pérez Díaz, Iván Martínez Duarte, Diana Alheli Mancilla Ortega, Juan Pablo |
| AuthorAffiliation | Tecnológico de Monterrey Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán |
| AuthorAffiliation_xml | – name: Tecnológico de Monterrey – name: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán |
| Author_xml | – sequence: 1 givenname: Hillary Kimberly surname: Osorio Landa fullname: Osorio Landa, Hillary Kimberly organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 2 givenname: Iván surname: Pérez Díaz fullname: Pérez Díaz, Iván organization: Instituto Nacional De Ciencias Médicas Y Nutrición Salvador Zubirán – sequence: 3 givenname: Sara Del Carmen surname: Laguna Bárcenas fullname: Laguna Bárcenas, Sara Del Carmen organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 4 givenname: Juan Manuel surname: López Navarro fullname: López Navarro, Juan Manuel organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 5 givenname: María Fernanda surname: Abella Roa fullname: Abella Roa, María Fernanda organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 6 givenname: Mariel surname: Corral Orozco fullname: Corral Orozco, Mariel organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 7 givenname: Juan Pablo surname: Mancilla Ortega fullname: Mancilla Ortega, Juan Pablo organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 8 givenname: Diana Alheli surname: Martínez Duarte fullname: Martínez Duarte, Diana Alheli organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 9 givenname: Susana Isabel surname: Morales Montalvo fullname: Morales Montalvo, Susana Isabel organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 10 givenname: Sebastián surname: Múzquiz Aguirre fullname: Múzquiz Aguirre, Sebastián organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán – sequence: 11 givenname: Elizabet surname: Sánchez Landa fullname: Sánchez Landa, Elizabet organization: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán |
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| Keywords | Vitamina D. Control glucémico. Diabetes mellitus de tipo 2. Enfermedad autoinmune. Mortalidad Glycemic control Control glucémico Enfermedad autoinmune Vitamin D Type-2 diabetes mellitus Mortality Mortalidad Autoimmune disease Diabetes mellitus de tipo 2 Vitamina D |
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publication-title: N Engl J Med |
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| Snippet | Introduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated.... INTRODUCTIONIntroduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well... Abstract Introduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well... |
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| StartPage | 335 |
| SubjectTerms | Adult Chronic Disease - mortality Diabetes Mellitus, Type 2 Female Humans Male Metabolic Diseases Nutrition & Dietetics Obesity Vitamin D - analogs & derivatives Vitamin D - biosynthesis Vitamin D - blood |
| Title | Association of serum vitamin D levels with chronic disease and mortality |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32054282 https://search.proquest.com/docview/2355952733 http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112020000300016&lng=en&tlng=en |
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