Importance of epigenetic changes in cancer etiology, pathogenesis, clinical profiling, and treatment: What can be learned from hematologic malignancies?

Epigenetic alterations represent a key cancer hallmark, even in hematologic malignancies (HMs) or blood cancers, whose clinical features display a high inter-individual variability. Evidence accumulated in recent years indicates that inactivating DNA hypermethylation preferentially targets the subse...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1836; no. 1; pp. 90 - 104
Main Authors:	Vecchio, Lorella, Seke Etet, Paul Faustin, Kipanyula, Maulilio John, Krampera, Mauro, Nwabo Kamdje, Armel Hervé
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-08-2013
Subjects:	Animals Anticancer treatment Cell Transformation, Neoplastic - pathology Chemoresistance Epigenetic processes Epigenomics Gene Expression Profiling Hematologic malignancy Hematologic Neoplasms - etiology Hematologic Neoplasms - pathology Hematologic Neoplasms - therapy Humans Interindividual variability Risk factors Hematologic malignancy Interindividual variability Epigenetic processes Risk factors Anticancer treatment Chemoresistance
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