Accurate quantitation of MHC-bound peptides by application of isotopically labeled peptide MHC complexes

Knowledge of the accurate copy number of HLA class I presented ligands is important in fundamental and clinical immunology. Currently, the best copy number determinations are based on mass spectrometry, employing single reaction monitoring (SRM) in combination with a known amount of isotopically lab...

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Bibliographic Details
Published in:	Journal of proteomics Vol. 109; pp. 240 - 244
Main Authors:	Hassan, Chopie, Kester, Michel G.D., Oudgenoeg, Gideon, de Ru, Arnoud H., Janssen, George M.C., Drijfhout, Jan W., Spaapen, Robbert M., Jiménez, Connie R., Heemskerk, Mirjam H.M., Falkenburg, J.H. Frederik, van Veelen, Peter A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 23-09-2014
Subjects:	Antigen Presentation - physiology Epitopes HLA-A Antigens - chemistry HLA-A Antigens - immunology hpMHC Humans Isotope Labeling - methods Peptides - analysis Peptides - immunology Quantitation SRM AQUA MS IP Epitopes Quantitation pMHC hpMHC SRM MiHA PE HLA HSCT EBV-LCL
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