Exosome-delivered syndecan-1 rescues acute lung injury via a FAK/p190RhoGAP/RhoA/ROCK/NF-κB signaling axis and glycocalyx enhancement

Acute lung injury (ALI) is characterized by protein-rich pulmonary edema, critical hypoxemia, and influx of pro-inflammatory cytokines and cells. There are currently no effective pharmacon therapies in clinical practice. Syndecan-1 in endothelial cells has potential to protect barrier function of en...

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Bibliographic Details
Published in:	Experimental cell research Vol. 384; no. 1; p. 111596
Main Authors:	Zhang, Chuankai, Guo, Feng, Chang, Mengling, Zhou, Zengding, Yi, Lei, Gao, Chengjin, Huang, Xiaoqin, Huan, Jingning
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2019
Subjects:	Acute lung injury Exosome Focal adhesion kinase (FAK) Glycocalyx p190RhoGAP Syndecan-1 Acute lung injury MPMVECs H&E O.E BALF Micro-CT SDC1-high-Exo p-P190 FAK Glycocalyx ECs Exosome p190RhoGAP Si Syndecan-1 SDC1 SDC1-low-Exo HPSE P190 Focal adhesion kinase (FAK) L/B ALI
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