Synthesis, structure determination, and antioxidant activity of novel 1-pyrazolyl-3-substituted isoquinolines, 1-pyrrolyl 3-substituted isoquinolin-1-amine, and 1-pyrazolonyl-substituted isoquinolines

• Published in: Research on chemical intermediates Vol. 41; no. 4; pp. 2081 - 2094
• Main Authors: Manivel, P., Prabakaran, K., Suneel, Y., Ghouse, S. M., Vivek, P. M., Ubba, E., Pugazhenthi, I., Khan, Fazlur-Rahman Nawaz
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-04-2015
• Subjects: Catalysis; Chemistry; Chemistry and Materials Science; Inorganic Chemistry; Physical Chemistry; Cyclocondensation of isoquinolinehydrazines; Pyrazolones; Pyrazole; Antioxidant property; Pyrrole
• ISSN: 0922-6168; 1568-5675
• DOI: 10.1007/s11164-013-1333-7

N
-substituted pyrazoles, pyrroles, and pyrazolones have been synthesized from 1,3 diketones, 1,4 diketones or α-haloesters, and hydrazinoisoquinolines. Reaction occurred at room temperature and furnished the desired products in excellent yields. The structures of the synthesized products were confirmed spectroscopically, including use of one dimensional
1
H and
13
C NMR spectroscopy and two-dimensional H,H-COSY and C,H-COSY. The antioxidant activity of the pyrazoles was evaluated and compared with that of the standard antioxidant BHT.
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