Variable resolution electromagnetic tomography (VARETA) in evaluation of compression of cerebral arteries due to deep midline brain lesions

• Published in: Archives of medical research Vol. 35; no. 3; pp. 225 - 230
• Main Authors: Fernández-Bouzas, Antonio, Harmony, Thalı́a, Fernández, Thalı́a, Ricardo-Garcell, Josefina, Santiago, Efraı́n
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2004
• Subjects: Adult; Brain Neoplasms - pathology; Brain vascular compression; Central and deep brain lesions; Cerebral Arteries - pathology; Cerebral Cortex - pathology; Computed tomography (CT); Electroencephalography - methods; Female; Humans; Magnetic resonance imaging (MRI); Magnetic Resonance Imaging - methods; Male; Middle Aged; Perfusion; Quantitative electroencephalography (qEEG); Tomography - methods; Tomography, X-Ray Computed - methods; Variable resolution electromagnetic tomography (VARETA); Brain vascular compression; Magnetic resonance imaging (MRI); Variable resolution electromagnetic tomography (VARETA); Central and deep brain lesions; Computed tomography (CT); Quantitative electroencephalography (qEEG)
• ISSN: 0188-4409; 1873-5487
• DOI: 10.1016/j.arcmed.2004.02.003

Hemispheric tumors produced electroencephalographic (EEG) delta activity mainly due to deafferentation of cerebral cortex. In small, deep midline lesions that compressed cerebral arteries, the most important abnormality should have been in EEG theta band that selectively responded to brain ischemia. Frequency domain-variable resolution electromagnetic tomography (FD-VARETA) has been applied satisfactorily to the study of brain tumors, cerebral infarcts, and brain hemorrhages and was shown to localize areas of hypoperfusion.
Twelve patients with deep midline lesions compressing different cerebral arteries were studied. Computer tomography (CT) and/or magnetic resonance imaging (MRI) as well as quantitative EEG with source calculation in frequency domain were obtained. Brain electromagnetic tomographies (BETs) were calculated to evaluate localization and extension of functional abnormalities.
Ten of twelve cases presented abnormal sources in theta band as main abnormal source. In only two cases was the main source in delta band, but these cases also had abnormal Z values in theta band. In four patients there were only abnormal values in theta range. Sources of abnormal theta activity were observed in regions irrigated by the arteries compressed.
In deep midline lesions, compression of cerebral arteries producing relative ischemia may explain abnormal EEG sources in theta band. Patients with main source in theta band showed vascular compression and some patients exhibited vasogenic edema. Thus, theta might be due to relative ischemia produced by both hypoperfusion and edema. Once again, VARETA has found to be very useful in evaluation of functional abnormalities.