Inhibitors of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Unmask Transcriptional Regulation of Hepatic Low-Density Lipoprotein Receptor Gene Expression by Dietary Cholesterol

The mechanism by which dietary cholesterol regulates expression of the hepatic low-density lipoprotein (LDL) receptor was investigated. In a previous study (Arch. Biochem. Biophys.325, 242–248, 1996), we demonstrated that dietary cholesterol reduces the rate of LDL receptor protein degradation witho...

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Bibliographic Details
Published in:	Archives of biochemistry and biophysics Vol. 344; no. 1; pp. 215 - 219
Main Authors:	Lopez, Dayami, Ness, Gene C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-1997
Subjects:	Animals Blotting, Northern CCAAT-Enhancer-Binding Proteins CHOLESTEROL Cholesterol, Dietary - pharmacology COLESTEROL DNA-Binding Proteins - metabolism Enzyme Inhibitors - pharmacology GENE Gene Expression Regulation - drug effects GENES Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunoblotting LDL receptor LIPOPROTEINAS LIPOPROTEINE Liver - metabolism lovastatin Lovastatin - pharmacology Male Northern blotting Nuclear Proteins - metabolism OXIDORREDUCTASAS OXYDOREDUCTASE Rats Rats, Sprague-Dawley Receptors, LDL - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 sterol response element binding proteins transcription Transcription Factors - metabolism Transcription, Genetic - drug effects Northern blotting transcription immunoblotting sterol response element binding proteins cholesterol lovastatin LDL receptor
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