In vivo gene therapy for prostate cancer: preclinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors

Advanced prostate cancer is invariably lethal once it becomes androgen independent (AI). With the aim of developing a new treatment we have used the human androgen-independent prostate cancer cell line, PC-3, to evaluate the effectiveness of two enzyme-directed prodrug therapy (EPT) systems as a nov...

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Bibliographic Details
Published in:	Human gene therapy Vol. 9; no. 11; p. 1617
Main Authors:	Martiniello-Wilks, R, Garcia-Aragon, J, Daja, M M, Russell, P, Both, G W, Molloy, P L, Lockett, L J, Russell, P J
Format:	Journal Article
Language:	English
Published:	United States 20-07-1998
Subjects:	Adenocarcinoma - therapy Adenoviridae - genetics Animals Escherichia coli - enzymology Ganciclovir - pharmacology Genetic Therapy Genetic Vectors Humans Male Mice Mice, Inbred BALB C Mice, Nude Prodrugs - pharmacology Prostatic Neoplasms - therapy Purine-Nucleoside Phosphorylase - genetics Purine-Nucleoside Phosphorylase - metabolism Simplexvirus - enzymology Thymidine Kinase - genetics Thymidine Kinase - metabolism Tumor Cells, Cultured
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