Ventilatory behavior and metabolism in two strains of obese rats

This study examined differences in metabolism and ventilatory responsiveness in the Zucker (Z) and Koletsky (K) rat which each carry a different recessive mutation of the leptin receptor gene. The Null hypothesis was that the obese (homozygous) rats from the strains would not differ among the variab...

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Bibliographic Details
Published in:	Respiration physiology Vol. 124; no. 2; pp. 85 - 93
Main Authors:	Strohl, Kingman P., Thomas, Agnes J.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier B.V 01-01-2001 Amsterdam Elsevier
Subjects:	Analysis of Variance Animals Biological and medical sciences Body Weight Carrier Proteins - genetics Energy Metabolism - genetics Energy Metabolism - physiology Female Gene, leptin receptor Genotype Hypercapnia - physiopathology Hypoxia - physiopathology Leptin receptor gene Male Mammals, rat Mediator, leptin Medical sciences Metabolic diseases Metabolism, obese rat, leptin receptor gene Mutation Obesity Obesity - genetics Obesity - physiopathology Obesity, rat, leptin Oxygen Consumption - genetics Oxygen Consumption - physiology Phenotype Pulmonary Gas Exchange - genetics Pulmonary Gas Exchange - physiology Pulmonary Ventilation - genetics Pulmonary Ventilation - physiology Rats Rats, Inbred Strains Rats, Zucker Receptor, leptin Receptors, Cell Surface Receptors, Leptin Thinness - genetics Thinness - physiopathology Tidal Volume - physiology Ventilation, obese rat Gene, leptin receptor Mediator, leptin Metabolism, obese rat, leptin receptor gene Mammals, rat Obesity, rat, leptin Receptor, leptin Ventilation, obese rat Leptin receptor gene Obesity Rat Peptide hormone Rodentia Nutrition disorder Metabolism Respiratory system Strain Vertebrata Mammalia Ventilatory response Animal Leptin Peptidergic receptor Respiratory quotient Gas exchange Pulmonary ventilation Respiration Nutritional status
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