Effect of garlic and garlic preparations on physiological and psychological stress in mice

• Published in: Phytotherapy research Vol. 11; no. 3; pp. 226 - 230
• Main Authors: Ushijima, Mitsuyasu, Sumioka, Isao, Kakimoto, Masanori, Yokoyama, Koji, Uda, Naoto, Matsuura, Hiromichi, Kyo, Eikai, Suzuki, Ayumi, Kasuga, Shigeo, Itakura, Yoichi, Petesch, Brenda L., Amagase, Harunobu
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-05-1997; Wiley
• Subjects: aged garlic extract; antistress effects in mice; Biological and medical sciences; garlic preparations; General pharmacology; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; physiological stress; stress; Monocotyledones; Pharmacognosy; Vegetable juice; Rodentia; Oral administration; Extract; Biological activity; Powder; Stress; Medicinal plant; Prevention; Liliaceae; Vertebrata; Mammalia; Folk medicine; Mouse; Animal; Angiospermae; Plant origin; Spermatophyta; Garlic; Allium sativum; Food
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/(SICI)1099-1573(199705)11:3<226::AID-PTR85>3.0.CO;2-E

The effect of several kinds of garlic preparations such as raw garlic juice (RGJ), heated garlic juice (HGJ), processed garlic powder (PGP) and aged garlic extract (AGE) on both physiological and psychological stress were investigated using four stress models in mice: forced swimming test, mechanical treadmill running, immobilization stress test, and a cooling rewarming test. RGJ was shown to be effective only at a low dose in the forced swimming test, whereas the effect was reduced at a high dosage. HGJ and PGP demonstrated no antistress effects. In contrast, AGE was shown to be effective in all of the stress tests. © 1997 by John Wiley & Sons, Ltd.