A novel synthesis of 3-Amino-1,2-benzisoxazoles - an entry into the isoxazolo[3,4,5-ef][1,4]benzoxazepine ring system

A novel synthesis of 3-Amino-1,2-benzisoxazoles - an entry into the isoxazolo[3,4,5-ef][1,4]benzoxazepine ring system

A novel synthesis of 3‐amino‐1,2‐benzisoxazole (3) from 2‐[(isopropylideneamino)oxy]benzonitrile (2) is described. This methodology was used to synthesize 3‐amino‐4‐hydroxy‐1,2‐benzisoxazole (10), which served as an intermediate for a number of isoxazolo[3,4,5‐ef][1,4]benzoxazepines....

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry Vol. 26; no. 5; pp. 1293 - 1298
Main Authors: Shutske, Gregory M., Kapples, Kevin J.
Format: Journal Article
Language:English
Published: Hoboken Wiley-Blackwell 01-09-1989
Wiley‐Blackwell
HeteroCorporation
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Organic chemistry
Preparations and properties
Phenols
Aromatic compound
Ketoxime
Tricyclic compound
Lactam
Oxygen nitrogen heterocycle
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel synthesis of 3‐amino‐1,2‐benzisoxazole (3) from 2‐[(isopropylideneamino)oxy]benzonitrile (2) is described. This methodology was used to synthesize 3‐amino‐4‐hydroxy‐1,2‐benzisoxazole (10), which served as an intermediate for a number of isoxazolo[3,4,5‐ef][1,4]benzoxazepines.
Bibliography:Dedicated to Professor Ernest Campaigne on the occasion of his 75th birthday
istex:18CB66D3DD1D304165A8311FC396EB3F073B924B
ArticleID:JHET5570260515
ark:/67375/WNG-7Z34NJZM-R
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570260515