Prevalence of Dyslipidemia in HIV-Positive Women with HPV Coinfection: A Preliminary Study

• Published in: Scientifica (Cairo) Vol. 2021; pp. 4318423 - 7
• Main Authors: Machado de Carvalho, Mônika, Donato Fook, Karina, José Abigail Mendes Araújo, Maria, Janayna Araújo Guimarães, Sulayne, Penha Abreu Souza, Camila, Déa Trindade Barbosa, Carla, Cléa Cutrim Diniz de Morais, Ana, Costa de Sales Muniz, Alessandra, Rocha de Araújo, Deborah, Bezerra Lima Bertolaccini, Maria Fernanda, Kassandra Pereira Belfort, Ilka, de Souza Andrade, Marcelo, Cristina Moutinho Monteiro, Sally
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 2021; Hindawi Limited
• ISSN: 2090-908X; 2090-908X
• DOI: 10.1155/2021/4318423

Objective. The present study aimed to evaluate the lipid profile and atherogenic indexes in HIV-positive women with and without coinfection with human papillomavirus. Methods. Preliminary study was conducted with HIV-positive women. Laboratory tests (lipid profile, glycid profile, and atherogenic indexes) and detection of human papillomavirus (nested PCR technique using PGMY 09 and 11 primers, GP+5, and GP+6) were performed. For the analysis of the results, the data were categorized into two groups: with coinfection (HIV+/HPV+) and without coinfection (HIV+/HPV–). Results. Eighty-two HIV-positive women, aged between 35 and 49 years, participated in this study among whom 50% had HPV coinfection (HIV+/HPV+). Regarding comorbidities, there was a predominance of dyslipidemia (46.3%). The analysis of laboratory determinations and atherogenic indexes showed statistical relevance in the serum concentrations of total cholesterol (p=0.04), LDL cholesterol (p=0.03), and non-HDL cholesterol (p=0.04), as well as for the Castelli I index, Castelli II index, and atherogenic coefficient (p=0.04, 0.04, and 0.03, respectively). Conclusion. The present study demonstrated a correlation between the lipid profile and atherogenic indexes with HIV/HPV coinfection, demonstrating a possible synergy between these viruses. However, further studies in this area must be carried out.