Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells

Interactions between estrogen receptor signaling and the PI3K/Akt pathway are present in estrogen-dependent cancer cells. Therapeutical inhibition of each of these pathways has been proven to exert antitumoral effects. Inhibition of mammalian target of rapamycin (mTOR), a downstream target of Akt, i...

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Bibliographic Details
Published in:	Gynecologic oncology Vol. 102; no. 2; pp. 292 - 299
Main Authors:	Treeck, Oliver, Wackwitz, Birgit, Haus, Ulrike, Ortmann, Olaf
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-2006
Subjects:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Growth Processes - drug effects Cell Line, Tumor Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Drug Synergism Endometrial adenocarcinoma Endometrial Neoplasms - drug therapy Endometrial Neoplasms - pathology Everolimus Female Humans mTOR Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Protein Kinases - biosynthesis Protein Kinases - genetics RAD001 RNA, Messenger - biosynthesis RNA, Messenger - genetics Sirolimus - administration & dosage Sirolimus - analogs & derivatives Sirolimus - pharmacology Tamoxifen - administration & dosage Tamoxifen - analogs & derivatives TOR Serine-Threonine Kinases mTOR Endometrial adenocarcinoma RAD001 Ovarian cancer
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