Intrastriatal folic acid mimics the distant but not local brain damaging properties of kainic acid

• Published in: Neuroscience letters Vol. 25; no. 2; p. 185
• Main Authors: Olney, J W, Fuller, T A, de Gubareff, T, Labruyere, J
• Format: Journal Article
• Language: English
• Published: Ireland 01-09-1981
• Subjects: Animals; Corpus Striatum - drug effects; Corpus Striatum - pathology; Folic Acid - toxicity; Kainic Acid - toxicity; Male; Pyrrolidines - toxicity; Rats; Seizures - chemically induced; Seizures - physiopathology
• ISSN: 0304-3940
• DOI: 10.1016/0304-3940(81)90329-3

Folic acid (pteroyl-L-glutamine acid, PGA), when injected into the rat striatum, has the kainic acid (KA) property of inducing sustained seizures and a disseminated pattern of distant brain damage, but lacks the KA property of destroying neurons locally at the injection site. This suggests the interesting possibility that one component of KA neurotoxicity (seizure-related distant damage) may involve interaction with a folate system. Folates are promising tools for exploring the neurotoxic properties of KA and, more importantly, for studying mechanisms of epilepsy and epileptic brain damage.