Caveolin-1 in meningiomas: expression and clinico-pathological correlations

• Published in: Acta neuropathologica Vol. 112; no. 5; pp. 617 - 626
• Main Authors: Barresi, V, Cerasoli, S, Paioli, G, Vitarelli, E, Giuffrè, G, Guiducci, G, Tuccari, G, Barresi, G
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01-11-2006
• Subjects: Adult; Aged; Aged, 80 and over; Caveolin 1 - genetics; Caveolin 1 - metabolism; Cell growth; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Ki-67 Antigen - metabolism; Kidney cancer; Male; Medical prognosis; Meningeal Neoplasms - genetics; Meningeal Neoplasms - metabolism; Meningeal Neoplasms - pathology; Meningioma - genetics; Meningioma - metabolism; Meningioma - pathology; Middle Aged; Predictive Value of Tests; Prognosis; Prostate; Signal transduction; Italy
• ISSN: 0001-6322; 1432-0533
• DOI: 10.1007/s00401-006-0097-1

Caveolin-1 (Cav-1) protein has been documented in several neoplasms with a controversial role in cell proliferation, tumour development and progression. The aim of the present study was to investigate the Cav-1 immunohistochemical expression in human meningiomas. Sixty-two cases, classified as 11 meningothelial (17%), 12 transitional (19%), 5 fibrous (8%), 3 microcystic (5%), 3 secretory (5%), 1 clear cell (2%), 1 chordoid (2%) and 26 (42%) atypical meningiomas, were selected from our pathological files. Clinico-pathological data, including Ki-67 values and survival data were also available. Ten leptomeningeal samples were utilized as normal tissue control. For each case, a polyclonal antibody against Cav-1 was applied and an intensity distribution (ID) score was determined. The Cav-1 immunoexpression was found in 95% of meningiomas with a variable ID score, while only minimal, not uniform, reactivity was noted in non-neoplastic meninges. Of note, higher Cav-1 ID score was significantly correlated with tumour site, Simpson's grade, histological type, higher histologic grade, Ki-67 labelling index > or = 4% and clinical course. Kaplan-Meier curves demonstrated a significantly worse survival in patients with higher Cav-1 ID score, Ki-67 > or = 4% and 2-3 Simpson grade. Multivariate analysis indicated that only Ki-67 was an independent prognostic factor. Increased immunoexpression of the Cav-1 seems to be associated with the biological aggressiveness of meningiomas, reflecting a worse prognosis.