Bladder carcinoma: results with preoperative radiation therapy and radical cystectomy

The records of 159 patients treated with preoperative radiotherapy and radical cystectomy were reviewed to ascertain the influence on survival rates and disease-free intervals of tumor stage, tumor grade, tumor appearance, lymphatic permeation, history of previous bladder tumors, and downstaging (pa...

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Published in:Urology (Ridgewood, N.J.) Vol. 16; no. 6; p. 569
Main Authors: Boileau, M A, Johnson, D E, Chan, R C, Gonzales, M O
Format: Journal Article
Language:English
Published: United States 01-12-1980
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Abstract The records of 159 patients treated with preoperative radiotherapy and radical cystectomy were reviewed to ascertain the influence on survival rates and disease-free intervals of tumor stage, tumor grade, tumor appearance, lymphatic permeation, history of previous bladder tumors, and downstaging (pathologic stage < clinical stage). Knowledge of grade, tumor appearance, lymphatic invasion, and history of previous bladder tumors did not make possible an accurate prediction of response to integrated therapy. However, both downstaging and the absence of muscle invasion were associated with significantly improved survival rates and disease-free intervals.
AbstractList The records of 159 patients treated with preoperative radiotherapy and radical cystectomy were reviewed to ascertain the influence on survival rates and disease-free intervals of tumor stage, tumor grade, tumor appearance, lymphatic permeation, history of previous bladder tumors, and downstaging (pathologic stage < clinical stage). Knowledge of grade, tumor appearance, lymphatic invasion, and history of previous bladder tumors did not make possible an accurate prediction of response to integrated therapy. However, both downstaging and the absence of muscle invasion were associated with significantly improved survival rates and disease-free intervals.
Author Johnson, D E
Boileau, M A
Gonzales, M O
Chan, R C
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Snippet The records of 159 patients treated with preoperative radiotherapy and radical cystectomy were reviewed to ascertain the influence on survival rates and...
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StartPage 569
SubjectTerms Carcinoma - mortality
Carcinoma - pathology
Carcinoma - therapy
Female
Humans
Lymphatic Metastasis
Male
Neoplasm Staging
Preoperative Care
Radiotherapy, High-Energy
Urinary Bladder - surgery
Urinary Bladder Neoplasms - mortality
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - therapy
Title Bladder carcinoma: results with preoperative radiation therapy and radical cystectomy
URI https://www.ncbi.nlm.nih.gov/pubmed/6777937
Volume 16
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