The effects of benzene exposure on apoptosis in epithelial lung cells: localization by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) and the immunocytochemical localization of apoptosis-related gene products

Although benzene, a well-known human carcinogen, has been shown to induce apoptosis in vitro, no studies have been carried out to confirm and characterize its role in activating apoptosis in vivo. The present study investigated the effects of benzene inhalation on the epithelial cells lining the res...

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Bibliographic Details
Published in:	Cell biology and toxicology Vol. 23; no. 3; pp. 201 - 220
Main Authors:	Weaver, C V, Liu, S-P, Lu, J-F, Lin, B-S
Format:	Journal Article
Language:	English
Published:	Netherlands Springer Nature B.V 01-05-2007
Subjects:	Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptotic Protease-Activating Factor 1 - metabolism Benzene Benzene - toxicity Biotin Bronchi - drug effects Bronchi - metabolism Bronchi - pathology Carcinogens - toxicity Caspases - metabolism Cytochromes c - metabolism Deoxyribonucleic acid DNA DNA Fragmentation - drug effects Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Humans Immunohistochemistry In Situ Nick-End Labeling Inhalation Labeling Lung - drug effects Lung - metabolism Lung - pathology Male Proteins Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Rats Rats, Sprague-Dawley Respiratory system Respiratory tract Rodents
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