Synthesis of prodrugs as bridged nucleosides

Methods for the preparation of N,N'-connected bisnucleosides have been developed. The bridge is formally a carbonate ester of N-hydroxymethyl nucleosides. Both symmetrical and non-symmetrical bridged bisnucleosides are available.

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Bibliographic Details
Published in:	Acta chemica Scandinavica (Copenhagen. 1989) Vol. 52; no. 10; p. 1270
Main Authors:	Hatlelid, J, Benneche, T, Undheim, K
Format:	Journal Article
Language:	English
Published:	Denmark 01-10-1998
Subjects:	Nucleosides - chemical synthesis Prodrugs - chemical synthesis
Online Access:	Get more information
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Description
Summary:	Methods for the preparation of N,N'-connected bisnucleosides have been developed. The bridge is formally a carbonate ester of N-hydroxymethyl nucleosides. Both symmetrical and non-symmetrical bridged bisnucleosides are available.
ISSN:	0904-213X
DOI:	10.3891/acta.chem.scand.52-1270