Antianginal effects of nitroglycerin during exercise-induced angina: Hemodynamic and left ventricular function changes related to indexes of myocardial oxygen consumption

In 14 patients during exercise, intravenous nitroglycerin improved anginal threshold and increased workload compared with control subjects. At similar workloads, the decreased left ventricular volumes suggested decreased myocardial oxygen consumption due to peripheral unloading. At maximal exercise...

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Bibliographic Details
Published in:	The American journal of cardiology Vol. 60; no. 15; pp. H10 - H14
Main Authors:	Choong, Christopher Y.P., Roubin, Gary S., Bautovich, George J., Harris, Phillip J., Kelly, David T.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 16-11-1987
Subjects:	Angina Pectoris - drug therapy Angina Pectoris - metabolism Angina Pectoris - physiopathology Blood Pressure Cardiac Output Heart Ventricles - physiopathology Hemodynamics Humans Injections, Intravenous Male Middle Aged Myocardium - metabolism Nitroglycerin - administration & dosage Nitroglycerin - therapeutic use Oxygen Consumption Physical Exertion Pulmonary Wedge Pressure Stroke Volume
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Summary:	In 14 patients during exercise, intravenous nitroglycerin improved anginal threshold and increased workload compared with control subjects. At similar workloads, the decreased left ventricular volumes suggested decreased myocardial oxygen consumption due to peripheral unloading. At maximal exercise with nitroglycerin (50 ± 17 to 79 ± 15 watts), rate-pressure product and end-diastolic volumes were higher with less ischemia, suggesting myocardial supply was improved by nitroglycerin.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9149 1879-1913
DOI:	10.1016/0002-9149(87)90544-3