Carbon Monoxide Reversibly Alters Iron Homeostasis and Respiratory Epithelial Cell Function

The dissociation of iron from heme is a major factor in iron metabolism and the cellular concentrations of the metal correlate with heme degradation. We tested the hypotheses that (1) exposure to a product of heme catabolism, carbon monoxide (CO), alters iron homeostasis in the lung and in cultured...

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Bibliographic Details
Published in:	American journal of respiratory cell and molecular biology Vol. 38; no. 6; pp. 715 - 723
Main Authors:	Ghio, Andrew J, Stonehuerner, Jacqueline G, Dailey, Lisa A, Richards, Judy H, Madden, Michael D, Deng, Zhongping, Nguyen, N.-B, Callaghan, Kimberly D, Yang, Funmei, Piantadosi, Claude A
Format:	Journal Article
Language:	English
Published:	United States Am Thoracic Soc 01-06-2008 American Thoracic Society
Subjects:	Acetaldehyde - metabolism Animals Antimetabolites - metabolism Antimetabolites - pharmacology Antioxidants - metabolism Bronchoalveolar Lavage Carbon Monoxide - metabolism Carbon Monoxide - pharmacology Cell Line Cell Proliferation Child Deferoxamine - metabolism Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Ferritins - metabolism Heme - chemistry Heme - metabolism Homeostasis Humans Interleukin-8 - metabolism Iron - metabolism Male Oxidative Stress Rats Rats, Sprague-Dawley Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Siderophores - metabolism
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