Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD

• Published in: Journal of the American Society of Nephrology Vol. 28; no. 6; pp. 1867 - 1876
• Main Authors: Schneider, Markus P, Raff, Ulrike, Kopp, Christoph, Scheppach, Johannes B, Toncar, Sebastian, Wanner, Christoph, Schlieper, Georg, Saritas, Turgay, Floege, Jürgen, Schmid, Matthias, Birukov, Anna, Dahlmann, Anke, Linz, Peter, Janka, Rolf, Uder, Michael, Schmieder, Roland E, Titze, Jens M, Eckardt, Kai-Uwe
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01-06-2017
• Subjects: Adult; Aged; Clinical Research; Cross-Sectional Studies; Female; Humans; Hypertrophy, Left Ventricular - complications; Hypertrophy, Left Ventricular - metabolism; Male; Middle Aged; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - metabolism; Skin - chemistry; Skin - metabolism; Sodium - analysis; Sodium - metabolism; Young Adult; skin; blood pressure; sodium; left ventricular hypertrophy; kidney diseases
• ISSN: 1046-6673; 1533-3450
• DOI: 10.1681/ASN.2016060662

The pathogenesis of left ventricular hypertrophy in patients with CKD is incompletely understood. Sodium intake, which is usually assessed by measuring urinary sodium excretion, has been inconsistently linked with left ventricular hypertrophy. However, tissues such as skin and muscle may store sodium. Using
sodium-magnetic resonance imaging, a technique recently developed for the assessment of tissue sodium content in humans, we determined skin sodium content at the level of the calf in 99 patients with mild to moderate CKD (42 women; median [range] age, 65 [23-78] years). We also assessed total body overhydration (bioimpedance spectroscopy), 24-hour BP, and left ventricular mass (cardiac magnetic resonance imaging). Skin sodium content, but not total body overhydration, correlated with systolic BP (
=0.33,
=0.002). Moreover, skin sodium content correlated more strongly than total body overhydration did with left ventricular mass (
=0.56,
<0.001 versus
=0.35,
<0.001;
<0.01 between the two correlations). Linear regression analysis demonstrated that skin sodium content is a strong explanatory variable for left ventricular mass, unaffected by BP and total body overhydration. In conclusion, we found skin sodium content to be closely linked to left ventricular mass in patients with CKD. Interventions that reduce skin sodium content might improve cardiovascular outcomes in these patients.