Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux

Cytochrome P450 1B1 (CYP1B1) mRNA is constitutively expressed in most normal extra‐hepatic tissues; however the protein is not detectable in these tissues but is expressed in a wide variety of tumors. CYP1B1 is responsible for the activation of a number of carcinogens present in tobacco smoke and fo...

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Bibliographic Details
Published in:	Molecular carcinogenesis Vol. 48; no. 2; pp. 110 - 117
Main Authors:	Devlin, Andrea H., McIlroy, Marie, McKeen, Hayley D., Bonde, Pramode, Menezes, A.A. Carlos, Swarbrick, Christine J., Robson, Tracy, Hirst, David G., Campbell, F. Charles, McGuigan, James A., McKeown, Stephanie R.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-02-2009
Subjects:	Animals Antibody Specificity Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - immunology Blotting, Western CYP1B1 Cytochrome P-450 CYP1B1 Duodenogastric Reflux - complications Duodenogastric Reflux - enzymology Esophageal Neoplasms - enzymology Esophageal Neoplasms - etiology esophagus Female Gastroesophageal Reflux - complications Gastroesophageal Reflux - enzymology Immunohistochemistry Mice Mice, Knockout Rats Rats, Sprague-Dawley RNA, Messenger - genetics rodent tumorigenesis
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