Cyclooxygenase-1 and Cyclooxygenase-2 Inhibition of Novel 1,2-Disubtituted Imidazoles

Novel 1,2‐disubstituted imidazoles were synthesized and tested for COX‐1 and COX‐2 inhibition. A substituted phenyl cycle in position 1 and an alicyclic tertiary alcohol in position 2 gave COX‐1‐selective compounds with potency and selectivity depending on the different substituents.

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Bibliographic Details
Published in:	Archiv der Pharmazie (Weinheim) Vol. 338; no. 12; pp. 602 - 604
Main Authors:	Handler, Norbert, Jaeger, Walter, Kuen-Krismer, Bea, Erker, Thomas
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-12-2005 WILEY‐VCH Verlag Wiley-VCH
Subjects:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents COX-Inhibition Imidazole Medical sciences Pharmacology. Drug treatments Imidazole derivatives Prostaglandin-endoperoxide synthase Enzyme Cyclooxygenase 2 Cyclooxygenase 1 Enzyme inhibitor Alcohol Cyclooxygenase 2 inhibitor In vitro Biological activity Cyclooxygenase 1 inhibitor Non steroidal antiinflammatory agent Imidazole Oxidoreductases COX-Inhibition Chemical synthesis
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Description
Summary:	Novel 1,2‐disubstituted imidazoles were synthesized and tested for COX‐1 and COX‐2 inhibition. A substituted phenyl cycle in position 1 and an alicyclic tertiary alcohol in position 2 gave COX‐1‐selective compounds with potency and selectivity depending on the different substituents.
Bibliography:	istex:B36613EE95C349D51305B036A8E0B1B4BE9659AE ArticleID:ARDP200500178 ark:/67375/WNG-XZPK0LQ5-5
ISSN:	0365-6233 1521-4184
DOI:	10.1002/ardp.200500178