Remote intrapulmonary spread of recurrent respiratory papillomatosis with malignant transformation

• Published in: Pediatric pulmonology Vol. 39; no. 2; pp. 185 - 188
• Main Authors: Katz, Sherri L., Das, Prabodh, Ngan, Bo‐Yee, Manson, David, Pappo, Alberto S., Sweezey, Neil B., Solomon, Melinda P.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-02-2005; Wiley-Liss
• Subjects: adenosquamous carcinoma; Adolescent; Biological and medical sciences; Biopsy, Needle; Carcinoma, Adenosquamous - diagnostic imaging; Carcinoma, Adenosquamous - pathology; Carcinoma, Adenosquamous - therapy; Cell Transformation, Neoplastic - pathology; cidofovir; Combined Modality Therapy; Diagnosis, Differential; Female; Follow-Up Studies; human papilloma virus; Humans; Laryngeal Neoplasms - diagnostic imaging; Laryngeal Neoplasms - pathology; Laryngeal Neoplasms - therapy; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - pathology; Lung Neoplasms - therapy; malignant transformation; Medical sciences; Neoplasm Recurrence, Local - pathology; Papilloma - diagnostic imaging; Papilloma - pathology; Papilloma - therapy; Pneumology; pulmonary nodules; pulmonary parenchymal involvement; Radiography, Thoracic; recurrent respiratory papillomatosis; Tomography, X-Ray Computed; Human; Adenosquamous carcinoma; Pediatrics; pulmonary nodules; Respiratory disease; Lung; pulmonary parenchymal involvement; Malignant tumor; human papilloma virus; Nodule; Virus; Recurrent respiratory papillomatosis; Malignant transformation; cidofovir; Papilloma; Benign neoplasm
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.20116

Recurrent respiratory papillomatosis is the most common neoplasm of the larynx in childhood. Extension into lung parenchyma occurs in less than 1% of patients and has a low risk of malignant transformation. Treatment options for intrapulmonary spread have shown limited success. We describe a case of recurrent respiratory papillomatosis with extensive parenchymal involvement and adenosquamous carcinoma in a 14‐year‐old girl. © 2004 Wiley‐Liss, Inc.