Terahertz optical measurements of correlated motions with possible allosteric function

Terahertz optical measurements of correlated motions with possible allosteric function

A suggested mechanism for allosteric response is the distortion of the energy landscape with agonist binding changing the protein structure’s access to functional configurations. Intramolecular vibrations are indicative of the energy landscape and may have trajectories that enable functional conform...

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Bibliographic Details
Published in:Biophysical reviews Vol. 7; no. 2; pp. 201 - 216
Main Authors: Niessen, Katherine A., Xu, Mengyang, Markelz, A. G.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-06-2015
Subjects:
Biochemistry
Biological and Medical Physics
Biological Techniques
Biomedical and Life Sciences
Biophysics
Cell Biology
Life Sciences
Membrane Biology
Nanotechnology
Review
Proteins
Far infrared
Normal modes
Allosteric response
Vibrational modes
Functional configurations
Terahertz
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Summary:A suggested mechanism for allosteric response is the distortion of the energy landscape with agonist binding changing the protein structure’s access to functional configurations. Intramolecular vibrations are indicative of the energy landscape and may have trajectories that enable functional conformational change. Here, we discuss the development of an optical method to measure the intramolecular vibrations in proteins, namely, crystal anisotropy terahertz microscopy, and the various approaches which can be used to identify the spectral data with specific structural motions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ObjectType-Review-1
ISSN:1867-2450
1867-2469
DOI:10.1007/s12551-015-0168-4