Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two blaKPC-2 gene copies without losing carbapenem resistance

Ceftazidime/Avibactam (CAZ/AVI) is frequently used to treat KPC-producing Pseudomonas aeruginosa (KPC-PA) and Enterobacterales . CAZ/AVI resistance is driven by several mechanisms. In P. aeruginosa this mainly occurs through alteration of AmpC, porins, and/or efflux pump overexpression, whereas in E...

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Bibliographic Details

Published in:	Frontiers in cellular and infection microbiology Vol. 12; p. 981792
Main Authors:	García, Patricia, Brito, Bárbara, Alcalde-Rico, Manuel, Munita, José M., Martínez, Jose R. W., Olivares-Pacheco, Jorge, Quiroz, Valeria, Wozniak, Aniela
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 02-09-2022
Subjects:	blaKPC-2 gene ceftazidime/avibactam resistance Cellular and Infection Microbiology D179Y substitution pseudomonas aeruginosa Tn4401b transposon
Online Access:	Get full text
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