Levodopa/carbidopa in the treatment of amblyopia

• Published in: Journal of pediatric ophthalmology and strabismus Vol. 46; no. 2; pp. 87 - 90
• Main Authors: Dadeya, Subhash, Vats, Pankaj, Malik, K P S
• Format: Journal Article
• Language: English
• Published: United States SLACK INCORPORATED 01-03-2009
• Subjects: Age groups; Amblyopia - drug therapy; Carbidopa - adverse effects; Carbidopa - therapeutic use; Child; Child, Preschool; Dopamine; Dopamine Agents - adverse effects; Dopamine Agents - therapeutic use; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa - adverse effects; Levodopa - therapeutic use; Male; Patients; Sensory Deprivation; Visual Acuity
• ISSN: 0191-3913; 1938-2405
• DOI: 10.3928/01913913-20090301-07

To evaluate the role of levodopa/carbidopa in the treatment of amblyopia.
Thirty patients with strabismic amblyopia between the ages of 3 and 12 years were part of this double-blind, randomized study. Patients were divided into two groups. Group A received 0.50 mg + 1.25 mg of levodopa/carbidopa per kilogram body weight three times daily after meals, with a protein rich drink, whereas Group B received placebo. Both groups received full-time conventional occlusion until a visual acuity of 6/6 was achieved or for a maximum of 3 months.
The authors observed more than two lines improvement in visual acuity that was greater in the levodopa group (15 of 15) than in the placebo group (9 of 15) (P < .005). Furthermore, improvement in visual acuity of more than two lines was greater in patients younger than 8 years (100%) than in patients older than 8 years of age (60%) (P = .0026). There was also no significant reversal of the improved visual acuity in up to 6 months of follow-up.
Levodopa/carbidopa improves visual acuity in patients with amblyopia and maintains improved visual acuity, especially in patients younger than 8 years.