Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in in vitro and in vivo models of renal cell carcinoma

The cell surface receptor CD70 has been previously reported as a promising target for B-cell lymphomas and several solid cancers including renal cell carcinoma. We describe herein the characterization and efficacy of a novel CD70 targeted thorium-227 conjugate (CD70-TTC) comprising the combination o...

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Bibliographic Details

Published in:	Oncotarget Vol. 8; no. 34; pp. 56311 - 56326
Main Authors:	Hagemann, Urs B, Mihaylova, Dessislava, Uran, Steinar R, Borrebaek, Joergen, Grant, Derek, Bjerke, Roger M, Karlsson, Jenny, Cuthbertson, Alan S
Format:	Journal Article
Language:	English
Published:	United States Impact Journals LLC 22-08-2017
Subjects:	Research Paper alpha particles renal cell carcinoma radioimmunotherapy targeted alpha therapy (TAT) thorium-227
Online Access:	Get full text
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